PECAM1
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Official Full Name
platelet/endothelial cell adhesion molecule 1 -
Overview
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] -
Synonyms
PECAM1;platelet/endothelial cell adhesion molecule 1;CD31;PECA1;GPIIA;PECAM-1;endoCAM;CD31/EndoCAM;platelet endothelial cell adhesion molecule;CD31 antigen;Pecam
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- Zebrafish
- Bovine
- HEK293
- E.coli
- C-His
- Insect Cell
- Human
- Mammalian Cell
- Human Cell
- HEK293F
- HEK293T
- Mammalian cells
- E.coli expression system
- Fc
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PECAM1 involved in several pathways and played different roles in them. We selected most pathways PECAM1 participated on our site, such as Cell adhesion molecules (CAMs),Leukocyte transendothelial migration,Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with PECAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | TNF,TLR2,CD40LG,THBS4,Ccl12,THBS2,CCL2,SDC1,GYPC,HGF |
| Leukocyte transendothelial migration | PRKCB,PRKCG,PLCG1,CLDN5,PIK3R2,RHOH,NCF2,PIK3R5,EZR,ACTN2 |
| Cell adhesion molecules (CAMs) | SELP,CLDN7,CLDN22,CLDN19,CLDN15LA,CD28,CLDN11B,SELPLG,ALCAM,CNTNAP2 |
Protein Function
PECAM1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PECAM1 itself. We selected most functions PECAM1 had, and list some proteins which have the same functions with PECAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZFP488,ZCCHC12,EWSR1,LUC7L2,NKX2-5,NR1H2,SART1,ANO2,ARHGAP26,ABL2 |
Interacting Protein
PECAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PECAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PECAM1.
PTPN11;JUP;SRC;CTNNB1
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References
- Xie, Q; Klesney-Tait, J; et al. Characterization of a novel mouse model with genetic deletion of CD177. PROTEIN & CELL 6:117-126(2015).
- Choi, JY; Ramasamy, T; et al. Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth. JOURNAL OF MATERIALS CHEMISTRY B 3:408-416(2015).
