NUDT21
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Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 21 -
Overview
The protein encoded by this gene is one subunit of a cleavage factor required for 3 RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3 end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. -
Synonyms
NUDT21;nudix (nucleoside diphosphate linked moiety X)-type motif 21;cleavage and polyadenylation specific factor 5, 25 kD subunit , cleavage and polyadenylation specific factor 5, 25 kDa , CPSF5;cleavage and polyadenylation specificity factor subunit
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- N-Twin strep and C-His&Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
NUDT21 involved in several pathways and played different roles in them. We selected most pathways NUDT21 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cleavage of Growing Transcript in the Termination Region | U2AF2,ZNF473,CSTF2,CSTF3,ZFP473,SRSF11,LSM10,THOC4,PAPOLA,CLP1 |
| Processing of Capped Intronless Pre-mRNA | CSTF2,CLP1,ZNF473,CSTF1,ZFP473,PAPOLA,LSM10,LSM11,SLBP,CSTF3 |
| mRNA 3-end processing | CSTF3,SRSF11,CSTF2,SFRS3A,CLP1 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPUL1,CSTF3,HNRNPD,SUGP1,CSTF2,DNAJC8,TXNL4A,METTL14,BCAS2,PTBP1B |
| Processing of Intronless Pre-mRNAs | PAPOLA,CLP1,CSTF3,CSTF2,CSTF1 |
| RNA Polymerase II Transcription Termination | LSM10,SRSF11,RNPS1,CSTF1,U2AF2,CSTF2,CSTF3,ZNF473,SLBP,ZFP473 |
| Gene Expression | ZNF18,ARHGEF38,ZNF157,POLR3GLA,ZNF649,RARG,DGCR8,CDK8,RNPC3,SNAPC1 |
| RNA Polymerase II Transcription | RNPS1,PAPOLA,SSRP1A,LSM11,ZNF473,SRSF11,CCNT2A,ZFP473,CSTF3,CSTF1 |
Protein Function
NUDT21 has several biochemical functions, for example, AU-rich element binding,contributes_to RNA binding,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT21 itself. We selected most functions NUDT21 had, and list some proteins which have the same functions with NUDT21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | CTSL.1,RNASEL4,Amy1,HELZ,ATP2A1L,CTDSPL2B,CES1D,LTV1,PLA2G2F,LACTB |
| protein homodimerization activity | MASP1,BCL2A1A,RENBP,ZFP423,HAND1,ASMT,SLC22A1,TYR,CACYBP,HES1 |
| protein binding | USP37,CRK,THBD,EZR,HMGB3,CALCRL,RNF19B,ANXA2,SLC16A3,CTAG1B |
| mRNA binding | C1QBP,TPR,XPO5,RPL35,THOC2,RPS5,MECP2,LUC7L2,HSP26,CELF3 |
| AU-rich element binding | ELAVL1,APOBEC1,ELAVL4,EXOSC8,EXOSC7,DND1,EXOSC9,ZFP36,HNRNPA0,ZFP36L1 |
| contributes_to RNA binding | CPSF6,LSM7,SMX5 |
| histone deacetylase binding | KAT2A,YWHAB,HIC1,SIRT2,ZMYND15,SRF,MEF2B,USF1,HDAC3,TOP2A |
| poly(A) RNA binding | MRPL28,DEK,HIST1H4F,SF3A1,DCN,HMGB2,SND1,PARP12,HIST1H4E,RPS24 |
Interacting Protein
NUDT21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT21 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT21.
CPSF7;CPSF6;TRIM27;GOLGA2;RNPS1
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