Lbp
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Official Full Name
lipopolysaccharide binding protein -
Overview
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. -
Synonyms
LBP;lipopolysaccharide binding protein;lipopolysaccharide-binding protein;BPI fold containing family D;member 2;BPIFD2;Ly88;BPI fold containing family D, member 2;LBP_HUMAN;LBP1;LPS binding protein;MGC22233;OTTHUMP00000030965;RP23-407H16.4;LPS-binding protein
Recombinant Proteins
- Mouse
- Human
- Cattle
- Pig
- Rat
- Rabbit
- Mammalian cells
- HEK293
- CHO
- NS0
- Mammalian Cell
- Wheat Germ
- E.coli
- Human Cell
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&GST
- His&Fc&Avi
- His&Myc
Involved Pathway
Lbp involved in several pathways and played different roles in them. We selected most pathways Lbp participated on our site, such as NF-kappa B signaling pathway,Toll-like receptor signaling pathway,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lbp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | PFN3,FLNB,PFN1,MYD88,ROCK2A,IL8L2,WASL,PKN1,WASB,NFKB1 |
| NF-kappa B signaling pathway | NFKBIA,IL1R1,BIRC2,TNFRSF1A,CD40,TRAF2,TRAF5,IL-8,ATM,CCL4 |
| Tuberculosis | HLA-DOB,MAPK11,NFYA,TNF,IFNA7,CAMP,CYCS,CD209C,ATP6V0A1,Casp3 |
| Toll-like receptor signaling pathway | MAP2K3,Ifna15,IFNA8,CCL4L2,IFNA16,CCL5,IL-8,TLR4BB,MYD88,STAT1 |
Protein Function
Lbp has several biochemical functions, for example, lipopolysaccharide binding,lipoteichoic acid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Lbp itself. We selected most functions Lbp had, and list some proteins which have the same functions with Lbp. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PROL1,PPP2R2B,ZYX,HAGH,INHA,EIF5A2,MRAS,PRAP1,HSPB8,SMAP2 |
| lipopolysaccharide binding | TRIL,SPON2,TREM2,KIAA0644,RNASE7,SELP,CD14,BPIFC,P2RX7,TLR4 |
| receptor binding | ACOX1,ANGPTL1,CXADR,FGG,C1QTNF2,PAOX,PLAT,TMEM38A,ANGPT2,ICOSLG |
| lipoteichoic acid binding | CD14,TREM2,TLR2,CD6 |
Interacting Protein
Lbp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lbp here. Most of them are supplied by our site. Hope this information will be useful for your research of Lbp.
PRDX4;SETD1A;CBFA2T2;FTH1;C4BPA;HSPB1;PSMA3;BAG6;SMAD3;BST1;TRA2A;PYCRL;TSC22D4;d-mannose
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References
- Zaitsev, BN; Benedetti, F; et al. Force-induced globule-coil transition in laminin binding protein and its role for viral-cell membrane fusion. JOURNAL OF MOLECULAR RECOGNITION 27:727-738(2014).
- Schrodl, W; Kruger, S; et al. Possible Effects of Glyphosate on Mucorales Abundance in the Rumen of Dairy Cows in Germany. CURRENT MICROBIOLOGY 69:817-823(2014).
