LY96
-
Official Full Name
lymphocyte antigen 96 -
Overview
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010] -
Synonyms
LY96;lymphocyte antigen 96;MD2;MD-2;ly-96;ESOP-1;protein MD-2;myeloid differentiation protein-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Cynomolgus
- E.coli
- Human Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- Baculovirus-Insect cells
- Mammalian cells
- Insect Cell
- HEK293T
- E. coli
- Mamanlian cells
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- Fc
- His&GST&Myc
- His&SUMO
- Flag&Myc
Involved Pathway
LY96 involved in several pathways and played different roles in them. We selected most pathways LY96 participated on our site, such as NF-kappa B signaling pathway,Toll-like receptor signaling pathway,Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with LY96 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | TUBB7P,TLR4,TUBA3D,ARHGEF2,NCK2,TUBA8,TUBA1A,ARPC5L,TUBA1C,ABL1 |
| Toll-like receptor signaling pathway | IL12BA,TLR4,TLR8,PIK3R5,CD80,TMED7-TICAM2,MAPK8B,CCL3L1,PIK3CB,IFNA8 |
| Pertussis | CALM1,ITGB1,Itgam&Itgb2,RHOA,GM5077,CASP1,MAPK13,IL6,TRAF6,GNAI3 |
| Toxoplasmosis | MYD88,Toxoplasma Gondii Microneme Protein MIC3,TGFB2,TAB2,HSPA6,BIRC2,IRGM1,LAMB2,CASP9,TLR2 |
| NF-kappa B signaling pathway | GM10591,TNF,TAB2,CCL21B,CCL13,CD40,IRAK4,TNFRSF1A,ZAP70,TNFAIP3 |
Protein Function
LY96 has several biochemical functions, for example, coreceptor activity,lipopolysaccharide receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LY96 itself. We selected most functions LY96 had, and list some proteins which have the same functions with LY96. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| coreceptor activity | HFE2,NRP1,CD80,CXCR4,RGMD,CD8A,RAMP2,CXCR7B,CD28,PVRL1 |
| protein binding | TIMM9,ARHGEF4,PRKAA2,ZAK,MYOC,APOA1BP,C4orf33,VPS37B,ATF5,GPN1 |
| lipopolysaccharide receptor activity | TLR2,SCARB1,PTAFR,TLR4 |
Interacting Protein
LY96 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LY96 here. Most of them are supplied by our site. Hope this information will be useful for your research of LY96.
TLR4;eritoran tetrasodium;tlr4_q4g1l2_tv8_prot;HMGB1;Hmgb1;CDKN2C
Resources
Research Area
NeuroinflammationImmune Regulatory Molecules on Endothelial Cells
Macrophage Markers
Monocyte Markers
Dendritic Cell Pathogen Recognition/Uptake
Related Services
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References
- Pishraft-Sabet, L; Kosinska, AD; et al. Enhancement of HCV polytope DNA vaccine efficacy by fusion to an N-terminal fragment of heat shock protein gp96. ARCHIVES OF VIROLOGY 160:141-152(2015).
- Lin, XF; Zhu, H; et al. Near-Infrared Fluorescence Imaging of Non-Hodgkin's Lymphoma CD20 Expression Using Cy7-Conjugated Obinutuzumab. MOLECULAR IMAGING AND BIOLOGY 16:877-887(2014).
