HSP90AA1
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Official Full Name
heat shock protein 90kDa alpha (cytosolic), class A member 1 -
Overview
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
HSP90AA1;heat shock protein 90kDa alpha (cytosolic), class A member 1;EL52;HSPN;LAP2;HSP86;HSPC1;HSPCA;Hsp89;Hsp90;LAP-2;HSP89A;HSP90A;HSP90N;HSPCAL1;HSPCAL4;heat shock protein HSP 90-alpha;HSP 86;heat shock 86 kDa;LPS-associated protein 2;heat shock 90kD protein 1, alpha;heat shock 90kDa protein 1, alpha;renal carcinoma antigen NY-REN-38;heat shock 90kD protein, alpha-like 4;epididymis luminal secretory protein 52;heat shock 90kD protein 1, alpha-like 4;lipopolysaccharide-associated protein 2
Recombinant Proteins
- Human
- Pig
- Rat
- Mouse
- Chicken
- Cynomolgus
- E.coli
- Insect Cell
- HEK293
- Sf9 Insect Cell
- Mammalian Cell
- Fermentation
- Synthetic
- Yeast
- HEK293T
- HeLa
- Mammalian cells
- His
- Non
- Myc&DDK
- His&MBP
- His&SUMO
- His&Fc&Avi
- GST
- Flag
Involved Pathway
HSP90AA1 involved in several pathways and played different roles in them. We selected most pathways HSP90AA1 participated on our site, such as Protein processing in endoplasmic reticulum,PIK-Akt signaling pathway,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90AA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | EP300,LEF1,WNT8B,GLI1,FLT3,TRAF2,FH1,BRAF,WNT5A,MMP1 |
| Antigen processing and presentation | HLA-DRB1,HLA-G,HSPA2,CALR,IFI30,H2-AA,HSPA6,CTSS,KIR2DS5,HLA-DRB4 |
| NOD-like receptor signaling pathway | CXCL2,NFKBIAB,IL1B,CASP1,CARD8,HSP90AA1.1,NFKBIAA,NAIP7,HSP90AA1.2,MAPK12A |
| PIK-Akt signaling pathway | ANGPT4,MET,IRS1,PPP2R5B,ITGA8,LAMA5,FLT4,Fgf15,F2R,IL3RA |
| Prostate Cancer | SMARCA4,GSTP1,MAPK1,CASP9,NRAS,ERBB2,MAP2K2,NFKB1,ARAF,AKT1 |
| Protein processing in endoplasmic reticulum | SSR1,MAPK8,CAPN1,ATF4,UBE4B,PKZ,DNAJB1,HYOU1,MAPK8B,RAD23AA |
| Progesterone-mediated oocyte maturation | ADCY1B,MAPK14B,RPS6KA2,RPS6KA3B,CDH1-A,MOS,RPS6KA3,ANAPC13,INSB,MAD1L1 |
| Estrogen signaling pathway | FKBP5,PIK3R1,CALM4,MAP2K2,GPR30,GNAI1,OPRM1,CALM3,HSPA8,HSPA6 |
Protein Function
HSP90AA1 has several biochemical functions, for example, ATP binding,ATPase activity,GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90AA1 itself. We selected most functions HSP90AA1 had, and list some proteins which have the same functions with HSP90AA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SAMD4,C14orf21,AKAP1,ZC3HAV1,RPL19,RBM8A,HSPA9,HIST1H4A,GPATCH8,RPS25 |
| GTPase binding | GOLGA4,RASA1,PTPRN,ENO1,GNB3,GNB2,LCP1,SPTBN1,VPS41,GM5506 |
| nitric-oxide synthase regulator activity | HSP90AA1.1,HSP90AB1,CALM2,AKT1,CALM1,ESR1,CALM3 |
| ATP binding | BMX,MYH9A,ACTR2,VPRBP,DDR2,GRK7B,CLPXA,CAMKVB,WNK1,MVD |
| nucleotide binding | RAB7,RND1L,PPIL4,BRAP,NSFB,SNRPA,HINT1,MXA,CKBA,ORC5 |
| protein homodimerization activity | PRPS2,SDS,CARM1,MIXL1,BCL2L10,BHLHE40,PON1,GRM6,Fzd4,JUP |
| TPR domain binding | STUB1,HSP90AB1,RAB8B,PDE2A |
| unfolded protein binding | HTRA2,CLPX,SYVN1,MKKS,CANX,CHAF1B,LRPAP1,CDC37L1,HSPA1L,TAPBP |
| ATPase activity | NSFA,KIFC3,HSPA8,DNAH6,HAND2,ABCG2D,NSFB,PMS2,MLH1,DNAH11 |
Interacting Protein
HSP90AA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90AA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90AA1.
CDC37;STUB1
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