HLA-E
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Official Full Name
major histocompatibility complex, class I, E -
Overview
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. -
Synonyms
HLA-E;major histocompatibility complex, class I, E;HLA class I histocompatibility antigen, alpha chain E;MHC HLA-E alpha-1;lymphocyte antigen;MHC HLA-E alpha-2.1;MHC class I antigen E;HLA class I histocompatibility antigen, E alpha chain;MHC;QA1;EA1.2;EA2.1;HLA-6.2;DKFZp686P19218
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- Insect Cell
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&Avi
- His&Fc&Avi
- Myc&DDK
- His&Myc
- Flag
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-E-3399H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | 23-303 aa | |
| HLA-E-1746H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | Gly22~Leu358 |
|
| HLA-E-4847H | Recombinant Human HLA-E Protein, GST-tagged | Wheat Germ | Human | GST | 1-358 a.a. |
|
| HLA-E-800HCL | Recombinant Human HLA-E cell lysate | Human | Non |
|
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| HLA-E-038H | Recombinant Human HLA-E protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
|
| HLA-E-039H | Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated | HEK293 | Human | His&Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
|
| HLA-E-040HP | Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | Human | His&Avi | Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide |
|
| HLA-E-1076H | Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
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| HLA-E-1076H-B | Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| HLA-E-1749H | Recombinant Human HLA-E Protein, MYC/DDK-tagged | HEK293T | Human | Myc&DDK |
|
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| HLA-E-2276H | Recombinant Human HLA-E protein, His&Myc-tagged | Insect Cell | Human | His&Myc | 22-305aa |
|
| HLA-E-268HFL | Recombinant Full Length Human HLA-E Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
|
| HLA-E-3602HF | Recombinant Full Length Human HLA-E Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 358 amino acids |
|
| HLA-E-3872H | Recombinant Human HLA-E protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 22-305aa |
|
Involved Pathway
HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | NADL1.2,ITGAV,NLGN2,CLDN1,CNTNAP2A,ITGB2,NCAM1A,NRXN3,CDH3,CLDN11A |
| Type I diabetes mellitus | HLA-DOB,HSPD1,GAD2,INS1,IL1B,CPE,IL12B,H2-AA,HLA-DOA,HLA-DPB1 |
| ne thyroid disease | IL4,Il2,HLA-DMB,IFNA21,IFNA14,HLA-DQB1,PRF1,HLA-DRB5,H2-AA,Fasl |
| Natural killer cell mediated cytotoxicity | KIR2DL4,KIR2DL3,PIK3R2,BID,PPP3R1,IFNA6,HLA-A,GZMB,TNFRSF10C,MAPK1 |
| Autoi | HLA-DOA,Fasl,H2-Q10,IFNA6,IL5,IFNA8,IFNA1,FASLG,HLA-DRB1,CD86 |
| Antigen processing and presentation | HLA-DOA,KIR2DS5,HLA-DPB1,PDIA3,HLA-DQB1,CD4,NFYC,HLA-G,HLA-DQA2,HSPA8 |
| Herpes simplex infection | HLA-DQB1,IFNPHI1,OAS1,HLA-A,SRSF7B,JAK2B,EP300,FAS,TBP,PER3 |
| Graft-versus-host disease | HLA-DPB1,CD86,GZMB,IFNG,KIR2DL1,Il2,HLA-DRB3,IL1A,HLA-G,HLA-F |
| Endocytosis | CBLC,SNX1A,EHD1B,IGF2R,PSD3,VPS37B,VPS24,SH3GL1B,PRKCI,CAV3 |
Protein Function
HLA-E has several biochemical functions, for example, MHC class I protein binding,beta-2-microglobulin binding,natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class I protein binding | Pilrb1,LILRB2,TUBB4B,PILRB2,VCP,ATP5A1,TUBB,BCAP31,PILRB,TAP1 |
| natural killer cell lectin-like receptor binding | ULBP2,MICB,CLEC2G,Raet1a,RAET1G,RAET1L,Mill2,ULBP1,CLEC2H,SAMD3 |
| peptide antigen binding | MAML1,MHC1UJA,HLA-DRB4,MHC1ZBA,HLA-DRB5,HLA-DQA1,MHC1UEA,HLA-G,MR1,TAP1 |
| beta-2-microglobulin binding | CD1A,H2-Q10,HLA-A,FCGRT,CD1E,CD1D,CD1B,CD1C,CD1D2,HFE |
| receptor binding | ECI2,NXPH3,CADM1,BMP2,NTF7,HIST2H3C2,MATK,MLN,Artn,DHRS4 |
Interacting Protein
HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac;TRAPPC2;fusA;lldD1;q5ni35_fratt;q7chg5_yerpe;proW;q7ckk6_yerpe;deoB;ptsG;y2173_bacan;q81wx2_bacan;dacF;q81z87_bacan;q8cl08_yerpe;sfcA2;leuB;PPP1R16A
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References
- Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
- Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).
