HAMP
-
Official Full Name
hepcidin antimicrobial peptide -
Overview
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] -
Synonyms
HAMP;hepcidin antimicrobial peptide;HEPC;PLTR;HFE2B;LEAP1;hepcidin;putative liver tumor regressor;liver-expressed antimicrobial peptide 1
Recombinant Proteins
- Human
- Zebrafish
- Cattle
- Mouse
- Pig
- Rat
- Larimichthys Crocea
- Dog
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293F
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- GST
- His
- Myc&DDK
- His&GST
- His&Fc
- Non
- His&KSI
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HAMP-280H |
Recombinant Human HAMP protein, GST-tagged
|
E.coli | Human | GST | ||
| HAMP-11623Z | Recombinant Zebrafish HAMP | Mammalian Cell | Zebrafish | His |
|
|
| HAMP-12H | Recombinant Human HAMP, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
|
| HAMP-2056C | Recombinant Cattle HAMP protein, His & GST-tagged | E.coli | Cattle | His&GST | Gln29~Thr82 |
|
| HAMP-2057H | Recombinant Human HAMP protein, His-tagged | E.coli | Human | His | Ser25~Thr84 |
|
| Hamp-2058M | Recombinant Mouse Hamp protein, His-tagged | E.coli | Mouse | His | Thr24~Thr83 |
|
| HAMP-2059P | Recombinant Pig HAMP protein, His & GST-tagged | E.coli | Pig | His&GST | Gly23~Thr82 |
|
| Hamp-2060R | Recombinant Rat Hamp protein, His & GST-tagged | E.coli | Rat | His&GST | Gly23~Thr84 |
|
| HAMP-4564H | Recombinant Human HAMP Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| HAMP-458H | Recombinant Human HAMP protein, His & Fc-tagged | HEK293F | Human | His&Fc | Ser25~Thr84 |
|
| HAMP-8408Z | Recombinant Zebrafish HAMP | Mammalian Cell | Zebrafish | His |
|
|
| HAMP-5640HCL | Recombinant Human HAMP 293 Cell Lysate | HEK293 | Human | Non |
|
|
| HAMP-2268L | Recombinant Larimichthys Crocea HAMP Protein (65-85 aa) | E.coli | Larimichthys Crocea | Non | 65-85 aa |
|
| HAMP-2732D | Recombinant Dog HAMP Protein, His&GST-tagged | E.coli | Dog | His&GST | Val23-Thr85 |
|
| Hamp-3354M | Recombinant Mouse Hamp Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| HAMP-3454HF | Recombinant Full Length Human HAMP Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 84 amino acids |
|
| HAMP-3599H | Recombinant Human HAMP Protein (Asp60-Thr84), N-GST tagged | E.coli | Human | GST | Asp60-Thr84 |
|
| HAMP-3600H | Recombinant Human HAMP Protein (Ser25-Thr84), His tagged | E.coli | Human | His | Ser25-Thr84 |
|
| Hamp-532R | Recombinant Rat Hamp protein, His-KSI-tagged | E.coli | Rat | His&KSI | 60-84a.a. |
|
| Hamp-6765M | Recombinant Mouse Hamp protein, GST-tagged | E.coli | Mouse | GST | 59-83aa |
|
| HAMP-9191HFL | Recombinant Full Length Human HAMP, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
|
| HAMP-955H | Recombinant Human HAMP Protein, His-tagged | HEK293F | Human | His | Ser25-Thr84 |
|
Involved Pathway
HAMP involved in several pathways and played different roles in them. We selected most pathways HAMP participated on our site, such as Iron metabolism in placenta, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Iron metabolism in placenta | IREB2,TFR2 |
Protein Function
HAMP has several biochemical functions, for example, copper ion binding,hormone activity,iron channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAMP itself. We selected most functions HAMP had, and list some proteins which have the same functions with HAMP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | MAP7,IZUMO1,TNFSF4,ANGPTL2,TNFSF8,TNFSF9,ANXA1,Ren1,TYROBP,NTF7 |
| hormone activity | FNDC5B,FSD1,STC2,UCN3,CRHR2,FSHB,UCN3L,PYY,SST6,IGF1 |
| copper ion binding | HEPH,TP53,HEPHL1A,COX11,CP,ATOX1,SNCA,PRNPA,COX17,DCT |
Interacting Protein
HAMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAMP here. Most of them are supplied by our site. Hope this information will be useful for your research of HAMP.
CKAP4;q9wmx2-pro_0000037550
Resources
Related Services
Related Products
References
- Tang, YH; Li, YY; et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25:675-682(2014).
- Li, X; Xu, F; et al. Allogeneic Transplantation, Fas Signaling, and Dysregulation of Hepcidin. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19:1210-1219(2013).
