GC
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Official Full Name
group-specific component (vitamin D binding protein) -
Overview
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] -
Synonyms
GC;group-specific component (vitamin D binding protein);DBP;GRD3;VDBG;VDBP;DBP/GC;HEL-S-51;vitamin D-binding protein;VDB;gc-globulin;vitamin D-binding alpha-globulin;epididymis secretory protein Li 51
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- RVFV
- E.coli
- HEK293
- Mammalian Cell
- NS0
- Mammalian cells
- Human Plasma
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- Yeast
- Insect Cell
- His
- His&T7
- His&GST
- Non
- HEK293
- Myc&DDK
- Flag
- His&Fc&Avi
- GST
- His&SUMO
Involved Pathway
GC involved in several pathways and played different roles in them. We selected most pathways GC participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Metabolism of steroid hormones and vitamin D, which may be useful for your reference. Also, other proteins which involved in the same pathway with GC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | SLC5A2,MED31,SLC25A32A,SLC25A32,MMADHC,NEU4,ACY3,MARCKSA,MOCOS,DPYD |
| Metabolism of steroid hormones and vitamin D | PPP1R2,CYP2R1,HSD17B11,CYP27B1,STARD5,AKR1B15,CYP24A1 |
| Metabolism of lipids and lipoproteins | PLIN2,CYP2V1,ALOX5AP,DPEP1,G0S2,AWAT2,YY2,OSBP,CHKB,CETP |
Protein Function
GC has several biochemical functions, for example, actin binding,calcidiol binding,vitamin D binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GC itself. We selected most functions GC had, and list some proteins which have the same functions with GC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| vitamin transporter activity | STRA6 |
| actin binding | MYH10,VPS18,MKL1,MYH11A,CAMK2B,PLEKHH2,ACE,CORO7,TPM3,MYBPC2 |
| vitamin D binding | CALB1,S100G,VDRA |
Interacting Protein
GC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GC here. Most of them are supplied by our site. Hope this information will be useful for your research of GC.
ACTA1;p29991-pro_0000037941;CCND3;GRB2;SERF2;RIF1;CDC73;PIK3R3;d-mannose;PPP2R2A
Resources
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References
- Sun, RY; Zhuang, HS; et al. An indirect competitive biotin-streptavidin enzyme-linked immunosorbent assay for the determination of dimethyl phthalate (DMP) in milk and milk products. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES 50:275-284(2015).
- Wernike, K; Brocchi, E; et al. A novel panel of monoclonal antibodies against Schmallenberg virus nucleoprotein and glycoprotein Gc allows specific orthobunyavirus detection and reveals antigenic differences. VETERINARY RESEARCH 46:-(2015).
