FUS
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Official Full Name
fused in sarcoma -
Overview
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009] -
Synonyms
FUS;fused in sarcoma;TLS;ALS6;ETM4;FUS1;POMP75;HNRNPP2;RNA-binding protein FUS;oncogene FUS;oncogene TLS;fus-like protein;75 kDa DNA-pairing protein;fusion gene in myxoid liposarcoma;translocated in liposarcoma protein;heterogeneous nuclear ribonucleoprotein P2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- HEK293T
- Mammalian cells
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- Myc&DDK
- Flag
- His
- Non
- His&Fc&Avi
- N-His&C-Myc
- N-His-MBP
Involved Pathway
FUS involved in several pathways and played different roles in them. We selected most pathways FUS participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | CD14,HOXA11,CEBPE,Itgam&Itgb2,ASPSCR1,FEV,PML,NFKB1,DEFA3,SUPT3H |
Protein Function
FUS has several biochemical functions, for example, DNA binding,RNA binding,estrogen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUS itself. We selected most functions FUS had, and list some proteins which have the same functions with FUS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin V binding | RAB11B,RAB14,RAB6A,RAB10,RAB6B,RAB3B,RAB27B,RAB3C,RAB25,RAB27A |
| estrogen receptor binding | NKX3-1,PADI2,DDX17,MED1,PRMT2,PPARGC1A,WIPI1,TAF10,CNOT1,TRIP4 |
| RNA binding | EIF1AXA,MKI67IP,MCTS2,RBM48,RBFOX1,PES,ZBP1,DUSP11,PABPN1,MOV10B.2 |
| poly(A) RNA binding | RBM39,XRCC5,YWHAG,HNRNPA2B1,CNOT4,TRIM56,DHX38,H1FX,TRMT1L,GTL3 |
| DNA binding | SYCP3,CHD8,ABI2,FOXJ1B,SOX3,TFCP2,PARP2,POU3F2B,TAF13,HIST1H4K |
| nucleotide binding | PRKCHB,NOL8,CLCN6,HNRNPABA,NSFB,SART3,DDX19,UBE2IA,GM7168,RHOAE |
| protein binding | HMGA1,CPNE6,TLDC2,FRMD8,CSRP2BP,PARP9,DRG2,EGF,DDO,EIF3G |
| identical protein binding | CLDN3,EPHA4,NDE1,AGER,CBS,PSMD4,LYZ1,CEP170L,APAF1,CLDN7 |
| transcription coactivator activity | BRD7,SUB1A,KAT6A,SMARCE1,TAF7L,GTF2F1,RUNX1,COPS5,JUNBA,CCNE1 |
Interacting Protein
FUS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUS here. Most of them are supplied by our site. Hope this information will be useful for your research of FUS.
PLEC;EWSR1;TAF15;DROSHA;fus_ddit3
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References
- Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
- Shimamura, M; Kyotani, A; et al. Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway. EXPERIMENTAL CELL RESEARCH 326:36-45(2014).
