FLT1

What is flt1 protein?

FLT1 stands for FMS-like tyrosine kinase 1, also known as vascular endothelial growth factor receptor 1 (VEGFR1). It is a type I transmembrane receptor tyrosine kinase that binds VEGF-A, VEGF-B, and PlGF ligands with high affinity. FLT1 plays a key role in blood vessel formation (vasculogenesis) and maturation (angiogenesis) during embryonic development and tissue remodeling.

What is the function of flt1 protein?

Angiogenesis: FLT1 signaling promotes endothelial cell proliferation, migration and survival, key steps in sprouting angiogenesis and blood vessel branch formation.

Vasculogenesis: During embryonic development, FLT1 helps in de novo blood vessel formation through vasculogenesis, the process of assembling endothelial progenitor cells into primitive vessels.

Vascular permeability: FLT1 activation increases permeability of endothelial cell junctions, allowing plasma components and cells to exit vessels during angiogenesis.

Flt1 related signaling pathway

PI3K-Akt pathway: FLT1 dimerization leads to recruitment and phosphorylation of PI3K, which activates PDK1 and Akt. Akt promotes cell survival, growth and metabolism.

PLCγ pathway: PLCγ is activated by FLT1 and generates IP3 and DAG. IP3 causes calcium release while DAG activates PKC. This regulates cell migration, survival and permeability.

Ras-Raf-MEK-ERK pathway: FLT1 activates GRB2/SOS complex which activates Ras. This triggers the Raf-MEK-ERK cascade, promoting cell proliferation and survival.

SRC family kinases: FLT1 recruits and activates c-SRC and other SRC kinases. They induce downstream signaling regulating migration, sprouting and permeability.

Focal adhesion kinase (FAK) pathway: FLT1 induces FAK phosphorylation which triggers reorganization of actin cytoskeleton and focal adhesions, controlling cell motility.

FLT1 Related Diseases

•  Preeclampsia: Abnormal placentation and reduced FLT1 signaling is implicated in the hypertensive disorder of pregnancy.
•  Cancer: Overexpression of FLT1/VEGF drives angiogenesis, invasion and metastasis in many tumors like breast and colon cancers.
•  Macular degeneration: Genetic risk factors exist involving FLT1 pathway in age-related degeneration of the eye's macula.
•  Atherosclerosis: FLT1 likely influences endothelial dysfunction and lesion formation in the artery-narrowing disease.
•  Cancer therapy: FLT1 inhibitors/antagonists are being developed to block tumor angiogenesis and growth.
•  Regenerative medicine: Delivery of FLT1 promotes revascularization of tissues/organs in transplants and repairs.
•  Wound healing: FLT1 enhances healing by inducing neovascularization of damaged dermal and epithelial tissues.
•  Ischemic disease treatment: Stimulating FLT1 signaling aids reperfusion of blood to ischemic tissues in heart attacks and strokes.
•  Diabetic ulcer/foot care: Angiogenesis induced via FLT1 improves healing of non-healing ulcers in diabetes.

•  Cancer therapy: FLT1 inhibitors/antagonists are being developed to block tumor angiogenesis and growth.
•  Regenerative medicine: Delivery of FLT1 promotes revascularization of tissues/organs in transplants and repairs.
•  Wound healing: FLT1 enhances healing by inducing neovascularization of damaged dermal and epithelial tissues.
•  Ischemic disease treatment: Stimulating FLT1 signaling aids reperfusion of blood to ischemic tissues in heart attacks and strokes.
•  Diabetic ulcer/foot care: Angiogenesis induced via FLT1 improves healing of non-healing ulcers in diabetes.

FLT1 has several biochemical functions, for example, ATP binding,VEGF-A-activated receptor activity,VEGF-B-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT1 itself. We selected most functions FLT1 had, and list some proteins which have the same functions with FLT1. You can find most of the proteins on our site.

FLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT1.

VEGFA;PTPRJ;PGF;PIK3R1;VEGFA;CRKL