Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), GST-tagged

• Cat.No.: FLT1-1015H
• Product Overview: Recombinant human FLT1 (784-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• ProteinLength: 784-end a.a.
• Description: FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS. The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers. In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 94 kDa
• Expression System: Sf9 insect cells using baculovirus
• Form: Recombinant protein stored in 50 mM Tris-HCl, PH 7.5, 150 mM NaCI, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
• Specific Activity: 40 nmol/min/mg
• Purity: >75%
• Concentration: 0.1 ug/ul
• Sequences: 784-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Focal adhesion; Glypican 1 network; HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilin interactions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; Signaling by VEGF; Signaling events mediated by VEGFR1 and VEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; VEGFR1 specific signals

Gene Information

• Gene Name: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [ Homo sapiens ]
• Official Symbol: FLT1
• Synonyms: FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; VEGFR1; vascular endothelial growth factor receptor 1; FLT-1; VEGFR-1; OTTHUMP00000018183; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor
• Gene ID: 2321
• mRNA Refseq: NM_002019
• Protein Refseq: NP_002010
• MIM: 165070
• UniProt ID: P17948
• Chromosome Location: 13q12
• Function: ATP binding; growth factor binding; identical protein binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity