Ephb3

  • Official Full Name

    EPH receptor B3
  • Overview

    Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
  • Synonyms

    EPHB3;EPH receptor B3;EphB3 , ETK2;ephrin type-B receptor 3;Hek2;Tyro6;EK2;EPH-like kinase 2;embryonic kinase 2;human embryo kinase 2;EPH-like tyrosine kinase 2;EPH-like tyrosine kinase-2;tyrosine-protein kinase TYRO6;ETK2

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • HEK293
  • E.coli
  • Insect Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Mammalian Cell
  • Human Cell
  • NS0
  • In Vitro Cell Free System
  • HEK293T
  • His
  • His&T7
  • GST
  • Non
  • His&Flag
  • Flag
  • His&GST
  • His&Fc&Avi
  • Myc&DDK
  • His&Fc
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
Ephb3-4051M Active Recombinant Mouse Ephb3 protein(Met1-Thr537), His-tagged HEK293 Mouse His Met1-Thr537
Ephb3-1160R Active Recombinant Rat Ephb3 Protein, His-tagged HEK293 Rat His 1-537 a.a.
Ephb3-1135M Recombinant Mouse Ephb3 protein, His & T7-tagged E.coli Mouse His&T7 Val628~Ile891
EPHB3-1214H Recombinant Human EPH Receptor B3, GST-tagged Insect Cell Human GST 623-907 a.a.
Ephb3-1728M Recombinant Mouse Eph Receptor B3 Mammalian cells Mouse Non
EPHB3-28578TH Recombinant Human EPHB3 Human Non 585-998 a.a.
EPHB3-305H Recombinant Human EPH Receptor B3, GST-tagged, Active Sf9 Insect Cell Human GST 585-end a.a.
EPHB3-3401H Recombinant Human EPHB3 Protein, GST-tagged Wheat Germ Human GST
EPHB3-376H Recombinant Human EPHB3 Protein, DDK/His-tagged HEK293 Human His&Flag Gly34-Leu559
EPHB3-377H Recombinant Human EPHB3 Protein, DDK-tagged Insect Cell Human Flag Met-Gly34-Leu559
EPHB3-563H Recombinant Human EPHB3 Mammalian Cell Human His
EPHB3-8627H Recombinant Human EPHB3, His & GST tagged Insect Cell Human His&GST 585-998 a.a.
EPHB3-001HCL Recombinant Human EPHB3 cell lysate Insect Cell Human Non 585-998 a.a.
EPHB3-2131MCL Recombinant Mouse EPHB3 cell lysate Human Cell Mouse Non
EPHB3-0991H Recombinant Human EPHB3 Protein (A2-V998), Tag Free Insect Cell Human Non A2-V998
EPHB3-0992H Recombinant Human EPHB3 Protein (A2-V998), GST tagged Insect Cell Human GST A2-V998
Ephb3-10547M Recombinant Mouse Ephb3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Ephb3-10547M-B Recombinant Mouse Ephb3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EPHB3-1900H Recombinant Human EPHB3 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
EPHB3-2871H Recombinant Human EPHB3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
EPHB3-2871H-B Recombinant Human EPHB3 Protein Pre-coupled Magnetic Beads HEK293 Human
Ephb3-29M Active Recombinant Mouse EphB3 Protein (Leu30-Thr537), C-Fc and 6×His tagged NS0 Mouse His&Fc Leu30-Thr537
EPHB3-30H Active Recombinant Human EPHB3 Protein (Leu38-Ala550), Fc tagged NS0 Human Fc Leu38-Ala550
EPHB3-4368HF Recombinant Full Length Human EPHB3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 998 amino acids
EPHB3-6641H Recombinant Human EPHB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Ephb3-957M Recombinant Mouse Ephb3 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    Ephb3 involved in several pathways and played different roles in them. We selected most pathways Ephb3 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ephb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance RHOA,UNC5D,ACTR2B,DPYSL4,SRGAP2,DUSP2,PAK4,CAP1,NRTN,PPP3R2

    Protein Function

    Ephb3 has several biochemical functions, for example, ATP binding,axon guidance receptor activity,ephrin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ephb3 itself. We selected most functions Ephb3 had, and list some proteins which have the same functions with Ephb3. You can find most of the proteins on our site.

    Function Related Protein
    axon guidance receptor activity GFRA3,SEMA5A,EPHA7,EPHB1,ROBO2,ROBO1
    ephrin receptor activity EPHA10,EPHA5,EPHB4B,EPHB4A,EPHB4,EPHB3A,EPHA2,EPHA2A,EPHA4A,EK1
    ATP binding TGFBR1,NAT1,DCAMKL2,IKBKE,MAP3K6,WARS2,PIK3C2B,SCYL1,KHK,LMTK3

    Interacting Protein

    Ephb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ephb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ephb3.

    npm_alk;saicar;PKM;MLLT4;GBE1;NFRKB;purvalanol b

    Resources

    References

    • Ronsch, K; Jagle, S; et al. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. MOLECULAR ONCOLOGY 9:335-354(2015).
    • McLaughlin, T; Lim, YS; et al. Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1. MOLECULAR AND CELLULAR NEUROSCIENCE 63:24-30(2014).

    Ask a Question for All Ephb3 Products

    Required fields are marked with *

    My Review for All Ephb3 Products

    Required fields are marked with *