EPHB4
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Official Full Name
EPH receptor B4 -
Overview
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to -
Synonyms
EPHB4;EPH receptor B4;EphB4 , HTK;ephrin type-B receptor 4;Tyro11;ephrin receptor EphB4;soluble EPHB4 variant 1;soluble EPHB4 variant 2;soluble EPHB4 variant 3;hepatoma transmembrane kinase;tyrosine-protein kinase TYRO11;tyrosine-protein kinase
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- E. coli
- Mammalian cells
- Sf9 Insect Cell
- Insect Cell
- Wheat Germ
- Insect Cells
- Human Cell
- Mouse
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- N-His
- His&Fc
- His&Flag
- Flag
- Fc
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EPHB4 involved in several pathways and played different roles in them. We selected most pathways EPHB4 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | MYL12A,DAB2IPB,SLC14A2,PAQR3B,JAK1,CD24,CAP1,ARPC1B,PPP3R1,SEMA7A |
Protein Function
EPHB4 has several biochemical functions, for example, ATP binding,ephrin receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHB4 itself. We selected most functions EPHB4 had, and list some proteins which have the same functions with EPHB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor activity | EPHB3A,EPHB4B,EPHA5,EPHB2B,EPHA6,EPHB3,EPHA4B,EPHB4A,EPHA4A,EPHA2 |
| protein binding | MAP3K3,TRIP10,USP20,FAM125B,EPHB6,FIS1,BLZF1,MST1,AGL,F7 |
| transmembrane receptor protein tyrosine kinase activity | INSRR,MUSK,EPHB2B,NPTNB,INSRA,ERBB2,EGFR,EPHA2,FGFR1A,ERBB4 |
| ATP binding | RNASEL,UCKL1,DCKL1B,SRR,SGK3,RIOK1,NEK3,STK16,AK4,NTRK3 |
Interacting Protein
EPHB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHB4.
bosutinib;dasatinib;saicar;ephopt;PKM;abl-tide;JUN;linkable pd173955 analogue;linkable vandetanib analogue;imatinib;purvalanol b;crizotinib;EGFR;ZSCAN5A;PARD6A;Skp1
Resources
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References
- Liu, SL; Li, D; et al. Design, Synthesis, and Validation of Axl-Targeted Monoclonal Antibody Probe for microPET Imaging in Human Lung Cancer Xenograft. MOLECULAR PHARMACEUTICS 11:3974-3979(2014).
- Nagano, K; Maeda, Y; et al. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. JOURNAL OF CONTROLLED RELEASE 189:72-79(2014).
