ENG
-
Official Full Name
endoglin -
Overview
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] -
Synonyms
ENG;endoglin;END;HHT1;ORW1;CD105 antigen;ORW;CD105
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Porcine
- Sus scrofa (Pig)
- E.coli
- HEK293
- Mammalian Cells
- Sf9 Cells
- Human Cells
- Insect Cells
- Rabbit
- CHO
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- StrepII
- His&Trx
- His&Fc&Avi
- Myc&DDK
- His&Avi
Involved Pathway
ENG involved in several pathways and played different roles in them. We selected most pathways ENG participated on our site, such as HIF-1-alpha transcription factor network,TGF Beta Signaling Pathway,TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF-1-alpha transcription factor network | NPM1,PLIN2,NDRG1,CP,COPS5,TFF3,CITED2,EGLN3,GATA2,ADM |
| TGF Beta Signaling Pathway | ZNF423,FST,TGFBR3,LEFTY1,ZFP423,FOXH1,RUNX3,NOG |
| TGF-beta Receptor Signaling Pathway | ZEB1B,COPS5,DAB2,ACVRL1,TGFBR3,FOXH1,HOXD9A,SKIA,TRAP1,VDRB |
Protein Function
ENG has several biochemical functions, for example, contributes_to BMP binding,activin binding,galactose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENG itself. We selected most functions ENG had, and list some proteins which have the same functions with ENG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| activin binding | ACVR2B,TGFBR3,FSTL3,ACVRL1,SMAD7,FKBP1A,ACVR1,FST,SMURF1 |
| glycosaminoglycan binding | Shh,EPYC,SERPINA5,PODXL2,EGFLAM,VIT,HABP2,CCDC80,DCN,SERPINE2 |
| galactose binding | GALK1,COLEC12,LGALS9,CLEC4F |
| contributes_to transforming growth factor beta binding | TGFBR2,TGFBR3,TGFBR1 |
| type I transforming growth factor beta receptor binding | SMAD2,SNX25,SMAD6,TGFB1,FKBP1A,TGFBR2,SMAD7,TGFB3 |
| type II transforming growth factor beta receptor binding | TGFBR1,TGFBR3,BAMBI,TGFB3,TGFB2,TGFB1,TGFB1A |
| transforming growth factor beta binding | HYAL2,THBS1,ACVR1,ITGAV,TGFBR2,CD109,LTBP4,TGFBR3,TGFBR1,LTBP1 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | CDKN1B |
| protein binding | PKP2,XAB2,GTPBP4,TRPC5,ASAP2,MYL12A,DAPK3,FAM9B,SYCP1,ACLY |
Interacting Protein
ENG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENG here. Most of them are supplied by our site. Hope this information will be useful for your research of ENG.
ITGA5;ITGB1;TGFB1;ganglioside_gm1;ARRB2;MMP14;ybgA;lutB;purH
Resources
Research Area
Cancer Drug TargetsEndothelial Cell Markers
Immune Regulatory Molecules on Endothelial Cells
Hemangioblast Markers
CD Antigen (Hematopoietic Stem Cell Markers)
Hematopoietic Stem Cell Markers
Mesenchymal Stem Cell Markers
Adipose-derived Stem Cell Markers
Macrophage Marker CD Antigen
Macrophage Markers
Monocyte Markers
Osteosarcoma Cancer Stem Cell Markers
Ovarian Cancer Stem Cell Markers
Mesodermal Lineage Markers
TGF-beta Family Receptor
Osteosarcoma Biomarkers
Related Services
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References
- Oke, O; Lettieri, P; et al. An investigation on the mechanics of homogeneous expansion in gas-fluidized beds. CHEMICAL ENGINEERING SCIENCE 127:95-105(2015).
- Cansiz, FBC; Dal, H; et al. An orthotropic viscoelastic material model for passive myocardium: theory and algorithmic treatment. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 18:1160-1172(2015).
