DNMT1
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Official Full Name
DNA (cytosine-5-)-methyltransferase 1 -
Overview
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] -
Synonyms
DNMT1;DNA (cytosine-5-)-methyltransferase 1;AIM;DNMT;MCMT;CXXC9;HSN1E;ADCADN;DNA (cytosine-5)-methyltransferase 1;m.HsaI;DNA MTase HsaI;DNA methyltransferase HsaI;CXXC-type zinc finger protein 9
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Insect Cells
- HEK293
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- His
- Non
- DDK
- Myc
- Flag
- GST
- T7
- Avi
- Fc
Involved Pathway
DNMT1 involved in several pathways and played different roles in them. We selected most pathways DNMT1 participated on our site, such as Cysteine and methionine metabolism,DNA methylation,Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MTM1,NDUFS4,POLR2L,ATP6V0E2,PHYKPL,TYR,NFS1,UQCR10,NOS2,CHPF |
| MicroRNAs in cancer | STAT3,ABCC1,MMP16,ATM,BMF,ERBB3,MAP2K1,MMP9,RPTOR,MCL1 |
| Cysteine and methionine metabolism | SDSL,AGXT2,BCAT1,GOT2B,DNMT3AB,MAT2AL,MAT2B,MPST,MDH2,CTH |
| Negative epigenetic regulation of rRNA expression | SUDS3,SAP30,SAP130,SAP30BP,TAF1C,CD3EAP,RRP8,SAP18,SAP30L,TAF1B |
| DNA methylation | DNMT3L,DNMT3B,DNMT3A,UHRF1 |
| Gene Expression | ZNF561,GTF3A,ZNF565,EIF2S1A,ZNF317,ZNF157,TRMT1,ZNF192,RRN3,TSEN2 |
| Epigenetic regulation of gene expression | SUZ12A,SMARCA5,SIN3B,BAZ2A,DNMT3A,TET3,H3F3D,H3F3B.1,TET2,JARID2 |
| NoRC negatively regulates rRNA expression | EFCAB11,SAP30L,TAF1A,CD3EAP,SAP130,SUDS3,SAP30BP,TAF1B,SIN3B,BAZ2A |
Protein Function
DNMT1 has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity,DNA binding,DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT1 itself. We selected most functions DNMT1 had, and list some proteins which have the same functions with DNMT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | MEF2A,HDGF2,RAD51,SUPT5H,CAMTA2,CCDC111,NFKB2,BRD2,NCAPD3,CREB3L1 |
| DNA binding | PKNOX1.1,POLE,CDX1A,GM14477,HIST1H4H,RXRAA,ASCL1A,NR4A1,SUB1B,HLTF |
| RNA binding | SRSF9,KHDC1C,NHP2L1A,PTBP2B,CPEB3,CELF1,FAM103A1,DIMT1,TRNAU1APB,DHX36 |
| zinc ion binding | TRAF2,ADH5,HHIP,SUV39H2,ADAMDEC1,MORC2A,DBF4,NR1H2,RNF170,TOPORS |
| DNA (cytosine-5-)-methyltransferase activity | DNMT3B,DNMT3A,TRDMT1 |
| DNA-methyltransferase activity | TRMT10C,RNMTL1B,METTL23,TRMT10B,FBLL1,DNMT3B,METTL7B,METTL21D,DNMT4,PRMT8B |
| protein binding | PSMD10,TADA2A,WBP1L,Aatk,SULT4A1,LDHB,GDPD5,PLK4,ARSI,CADPS |
| methyl-CpG binding | MBD3A,ZNF295,ZBTB4,MBD1,MECP2,UHRF1,ZBTB33,LRWD1,MBD1B,MBD3L1 |
| transcription factor binding | KEAP1B,TCF3,TCF12,PPRC1,EPAS1,SIRT2,SLC26A5,EGR1,PAXBP1,NKX3-1 |
Interacting Protein
DNMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT1.
Resources
Research Area
DNA methyltransferases (DNMTs)Cancer Stem Cell Transcription Factors
Epithelial Stem Cell Transcription Factors
Epigenetics and EMT
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References
- Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
- Yuan, LQ; Chan, GCF; et al. RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF alpha in the microenvironment. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:1834-1838(2014).
