CYP2C9

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 9

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

  • Synonyms

    CYP2C9;cytochrome P450, family 2, subfamily C, polypeptide 9;CPC9;CYP2C;CYP2C10;CYPIIC9;MGC88320;P450IIC9;MGC149605;cytochrome P450 2C9;OTTHUMP00000020135;cytochrome P-450MP;cytochrome P450 PB-1;microsomal monooxygenase;xenobiotic monooxygenase;flavoprotein-linked monooxygenase;cytochrome P-450 S-mephenytoin 4-hydroxylase

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Cynomolgus
  • E.coli
  • Mammalian Cell
  • P.pastoris
  • Wheat Germ
  • HEK293
  • Insect Cell
  • In Vitro Cell Free System
  • Mamanlian cells
  • Non
  • His
  • GST
  • Myc&DDK
  • His&Myc
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP2C9-543H Active Recombinant Human CYP2C9 1(Wild type allele) E.coli Human Non
CYP2C9-544H Active Recombinant Human CYP2C9 2 (R144C) E.coli Human Non
CYP2C9-545H Active Recombinant Human CYP2C9 3 (I359L) E.coli Human Non
CYP2C9-1151R Recombinant Rhesus monkey CYP2C9 Protein, His-tagged Mammalian Cell Rhesus macaque His
CYP2C9-35H Recombinant Human CYP2C9/NADPH reductase protein P.pastoris Human Non
CYP2C9-363H Recombinant Human CYP2C9/NADPH protein, Active P.pastoris Human Non
CYP2C9-530H Recombinant Human CYP2C9, GST-tagged Wheat Germ Human GST 1 a.a. - 162 a.a.
CYP2C9-531H Recombinant Human CYP2C9 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
CYP2C9-537H Recombinant Human CYP2C9 Insect Cell Human Non
CYP2C9-7113HCL Recombinant Human CYP2C9 293 Cell Lysate HEK293 Human Non
CYP2C9-113HF Recombinant Full Length Human CYP2C9 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1 a.a. - 162 a.a.
CYP2C9-125C Active Recombinant Cynomolgus CYP2C9 Protein E.coli Cynomolgus
CYP2C9-22H Active Recombinant Human CYP2C9 Protein E.coli Human
CYP2C9-2795H Recombinant Human CYP2C9 protein, His&Myc-tagged E.coli Human His&Myc 1-162aa
CYP2C9-4976HFL Recombinant Full Length Human CYP2C9 protein, Flag-tagged Mamanlian cells Human Flag Full L.
CYP2C9-74H Active Recombinant Human CYP2C9 Protein E.coli Human
CYP2C9-976R Recombinant Rhesus Macaque CYP2C9 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CYP2C9-976R-B Recombinant Rhesus Macaque CYP2C9 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Kit-0898 CYP2C9 Green Screening Kit Non
Kit-0915 CYP2C9 Blue Screening Kit Non
Kit-0936 CYP2C9 Red Screening Kit Non
Kit-2116 Cytochrome P450 2C9 Activity Fluorometric Assay Kit Non
Kit-2117 Cytochrome P450 2C9 Inhibitor Screening Kit Non

    Involved Pathway

    CYP2C9 involved in several pathways and played different roles in them. We selected most pathways CYP2C9 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase,Arachidonic acid metabolism,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism FAAH2B,ALOX5A,CYP2J2,ALOX12E,PLA2G10,CYP4A11,PTGS2B,GGT1A,CYP2C54,PLB1
    CYP2E1 reactions CYP2B6,CYP2A13,CYP2F1,CYP2Y3,CYP2E1,CYP2C19,CYP2A7,CYP2C8,CYP2S1,CYP2D6
    Biological oxidations ADH5,CYP46A1,CYP8B2,AS3MT,CYP1A1,CYP2W1,CYP4T8,AKR1A1,CYP17A1,CYP2C8
    Drug metabolism - cytochrome P450 CYP2C19,ADH2-2,CYP2D6,ADH1B,ADH4,CYP2B6,ADH1A,CYP2A6,ADH2-1,ADH5
    Linoleic acid metabolism PLA2G4D,PLA2G2E,CYP2C55,PLA2G2F,PLA2G10,CYP2P6,CYP3A41B,CYP2C54,PLA2G5,CYP2P8
    Arachidonate Epoxygenase / Epoxide Hydrolase COX8A,CYP2J2
    Cytochrome P450 - arranged by substrate type CYP2S1,CYP1B1,CYP3A5,CYP2K6,POMCB,CYP17A1,CYP11B1,CYP2A6,CYP4B1,CYP2AD6
    Chemical carcinogenesis CYP2A6,CCBL2,CBR1,CYP3A41B,GSTM6,UGT1A6A,ADH1,UGT2B15,UGT1A2,UGT2B7

    Protein Function

    CYP2C9 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity,(S)-limonene 6-monooxygenase activity,(S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C9 itself. We selected most functions CYP2C9 had, and list some proteins which have the same functions with CYP2C9. You can find most of the proteins on our site.

    Function Related Protein
    (R)-limonene 6-monooxygenase activity CYP2C8,CYP2C19
    monooxygenase activity CYP2X10.2,CYP2X8,CYP2AA2,CYP2E1,CYP2C19,MICAL2,CYP2K6,CYP2C50,CYP2C18,CYP2P8
    arachidonic acid epoxygenase activity CYP2C19,CYP2D10,CYP4F2,CYP2C54,CYP2D26,CYP2C70,CYP2Y3,CYP2P8,CYP2C8,CYP2AA3
    oxygen binding CYP2A12,CYP2P9,CYGB,HBBE3,CYP2AA1,CYP2P10,NGB,Adgb,CYP2C19,CYP2E1
    heme binding HBG2,CYP19A1,TDO2,CYP7A1,DUOX2,CYP2E1,NOS2,CYP2AD3,CYP2A4,CYBB
    caffeine oxidase activity CYP1A2,CYP2C38,FAM84B,CYP2C39,CYP3A4
    (S)-limonene 7-monooxygenase activity CYP2C8,CYP2C19
    steroid hydroxylase activity CYP2K22,CYP2A7,CYP27A1,CYP2AD2,CYP2P6,CYP2AA8,CYP2F1,CYP2E1,CYP46A1.4,CYP2U1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2K18,CYP2X8,CYP2AA4,CYP2AA2,CYP2X10.2,CYP1A,CYP2D6,CYP2K19,CYP2X9,CYP2V1

    Interacting Protein

    CYP2C9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C9.

    STAMBP;RAB3D;STAT5A;CDC37;RNF32;MAST1

    Resources

    References

    • Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    • Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).

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