CHMP2B
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Official Full Name
charged multivesicular body protein 2B -
Overview
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008] -
Synonyms
CHMP2B;charged multivesicular body protein 2B;DMT1;ALS17;VPS2B;VPS2-2;CHMP2.5;charged multivesicular body protein 2b;VPS2 homolog B;chromatin modifying protein 2B;vacuolar protein-sorting-associated protein 2-2
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- Human
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CHMP2B involved in several pathways and played different roles in them. We selected most pathways CHMP2B participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CAV1,RAB7,WASB,ARPC1B,ZFP652,TGFBR1A,STAMBPB,DNM2B,KIF5C,CCDC53 |
Protein Function
CHMP2B has several biochemical functions, for example, protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP2B itself. We selected most functions CHMP2B had, and list some proteins which have the same functions with CHMP2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | YWHAE1,RHOA,ESRRA,EHD2,HIST1H4H,DBNL,AKAP1,HSPA5,TUBB,SNCA |
| protein binding | TCP1,RNF19B,KLF11,GSK3B,ENDOG,ACLY,SIAH1A,CRYAB,IL23R,HRG |
Interacting Protein
CHMP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP2B.
TERF2IP;USP8;USP54;NR4A1;VHL;ATP5C1;TRAF2;Bub1;ATP6AP2;LTN1;Rab5c;Bmpr1a;ATP6V1A;Vps4b;RAB5C;RAB7A;Tceb1;Jup;MAD2L1
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References
- Nakamori, M; Takahashi, T; et al. Molecular Markers for Granulovacuolar Degeneration Are Present in Rimmed Vacuoles. PLOS ONE 8:-(2013).
- Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).
