CH25H
-
Official Full Name
cholesterol 25-hydroxylase -
Overview
This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. -
Synonyms
CH25H;cholesterol 25-hydroxylase;C25H;Cholesterol 25 hydroxylase;Cholesterol 25 monooxygenase;h25OH;OTTHUMP00000020057;cholesterol 25-monooxygenase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Mus musculus
- Sus scrofa (Pig)
- zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CH25H involved in several pathways and played different roles in them. We selected most pathways CH25H participated on our site, such as Primary bile acid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CH25H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary bile acid biosynthesis | CYP46A1.2,CYP7B1,AKR1D1,BRSK2,AKR1C4,CH25HL1.2,HSD3B7,CH25HL2,ACOX2,CYP46A1.1 |
Protein Function
CH25H has several biochemical functions, for example, cholesterol 25-hydroxylase activity,iron ion binding,steroid hydroxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CH25H itself. We selected most functions CH25H had, and list some proteins which have the same functions with CH25H. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid hydroxylase activity | CYP2Y3,CYP2C37,CYP2AA3,CYP2J6,CYP2K19,CYP2A4,CYP2A6,CYP2C9,CYP2P6,CYP2U1 |
| iron ion binding | CYP4F11,Scd1,EGLN1B,ALOX8,P4HA2,ALOX5B.3,CYP4A10,CYP7A1,CYP2D9,CYP3A4 |
| cholesterol 25-hydroxylase activity | BRSK2 |
Interacting Protein
CH25H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CH25H here. Most of them are supplied by our site. Hope this information will be useful for your research of CH25H.
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