CENPA
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Official Full Name
centromere protein A -
Overview
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. -
Synonyms
CENPA;centromere protein A;Cenp-A;histone H3-like centromeric protein A;centrosomin A;centromere autoantigen A
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- HEK293
- Yeast
- E.coli
- In Vitro Cell Free System
- GST
- His
- Non
- Avi&His&Fc
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CENPA involved in several pathways and played different roles in them. We selected most pathways CENPA participated on our site, such as Aurora A signaling,Aurora B signaling,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| M Phase | NIPBL,CTDNEP1B,ENSAA,GORASP2,SGOL1,NEK9,CENPI,LEMD3,SMC2,CDCA8 |
| Cell Cycle, Mitotic | CDKN2D,CEP290,NDEL1B,PANE1,OFD1,DCTN1,CSNK2A2,ENSAB,CNEP1R1,SET |
| Aurora A signaling | GADD45A,AURKAIP1,AURKB,OAZ1,TACC3,TPX2,TACC1,NDEL1,TDRD7 |
| Chromosome Maintenance | TERF2IP,HJURP,APITD1,NPM1,CENPW,POLD3,MLF1IP,POT1A,RBBP4,MIS18A |
| Deposition of new CENPA-containing nucleosomes at the centromere | APITD1,MLF1IP,CENPW,CENPC1,SMARCA5,CENPO,OIP5,PANE1,CENPK,MIS18BP1 |
| Aurora B signaling | NSUN2,AURKB,NCAPD2,NDC80,SEPT1,CBX5,INCENP,NPM1,SGOL1,SMC4 |
| FOXM1 transcription factor network | CHEK2,FOXM1,CENPB,AURKB,CKS1B |
| Cell cycle | CEP78,KNTC1,RAD1,KAT5,NCAPG2,CLIP1,DHFR,HUS1,BRE,CENPE |
Protein Function
CENPA has several biochemical functions, for example, DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPA itself. We selected most functions CENPA had, and list some proteins which have the same functions with CENPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | BMP7A,SLC3A1,UGT1A7,NR2C2,EPAS1,TLX1,HIST2H4A,MYF6,ERBB2,LTC4S |
| chromatin binding | HESX1,SOX10,PHF8,CAPNS2,REST,CUX1,MEOX1,SMC3,KDM5A,URI1 |
| DNA binding | ENO1,CSDC2,NR0B2A,HIST1H2BC,SMUG1,RARG,ZSCAN5A,FBXL19,KDM5B,POLR2C |
| protein binding | NRG1,TH,HDAC10,ZMAT3,DYNLT3,KHDC3,TGIF2LY,CUL9,ZNF511,TRAM1 |
Interacting Protein
CENPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPA here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPA.
HJURP;HIST2H4B;NPM1
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References
- Low, AHL; Wong, S; et al. Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. RHEUMATOLOGY 51:1465-1470(2012).
- Francis, GD; Stein, SR; et al. Prediction of histologic grade in breast cancer using an artificial neural network. 2012 INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS (IJCNN) :-(2012).
