CASP2
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Official Full Name
caspase 2, apoptosis-related cysteine peptidase -
Overview
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
Apoptosis related cysteine peptidase;CASP 2;Casp 2L Pro;CASP2;Caspase 2 apoptosis related cysteine protease;Caspase2;Developmentally down regulated 2;ICH 1;ICH 1 protease;ICH 1L;ICH 1L/1S;ICH1;ICH1 protease;ICH1L/1S;NEDD 2;NEDD2 apoptosis regulatory gene;Neural precursor cell expressed;Neural precursor cell expressed developmentally down regulated 2;OTTHUMP00000025259;OTTHUMP00000202227;neural precursor cell expressed developmentally down-regulated protein 2;EC 3.4.22.55;Protease ICH-1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Chicken
- Arabidopsis thaliana
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- His&SUMO
Involved Pathway
CASP2 involved in several pathways and played different roles in them. We selected most pathways CASP2 participated on our site, such as Apoptosis,Apoptosis Modulation and Signaling,Apoptosis Modulation by HSP70, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | ITGB3BP,TIAM2,OBSCN,MCF2L,ARHGEF16,KALRNB,ARHGAP4A,ARHGAP4,ECT2,ARHGEF17 |
| Immune System | LRR1,KPNA3,CD200R3,DEFA6,TNRC5,TREML4,SIRPB1,TPP2,DZIP3,SIGLEC11 |
| Caspase cascade in apoptosis | ACTA1,DFFA,CFL2,LMNB1,TOP1,TFAP2A,NUMA1,SATB1,CRADD,GAS2 |
| Innate Immune System | CRP,ABI1,NLRP3,NCKIPSD,TXNIPA,ART1,SIGLEC14,PPAPDC1A,TLR6,TREX1 |
| Apoptosis Modulation and Signaling | BOK,HRK,DAXX,CDKN2A,PTRH2,CRADD,BCL2L11,DIABLO,CAPNS1,SEPT4 |
| Apoptosis Modulation by HSP70 | DERL3 |
| HIV-1 Nef: Negative effector of Fas and TNF-alpha | DAXX,CRADD,DFFA |
| Apoptosis | PPP3R1,RELA,CASP6L1,BIRC8,IRF1B,PRKACBB,LMNB1,MYC,IKBKG,CAPN2A |
Protein Function
CASP2 has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type endopeptidase activity involved in apoptotic signaling pathway,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP2 itself. We selected most functions CASP2 had, and list some proteins which have the same functions with CASP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | PLAUR,H2AFX,ZNF346,RAD9,TSPAN10,TOP2B,SORT1,PEX5,LDB1,CAD |
| protein binding | HYLS1,BCL2L14,FUBP1,APOA2,TRAK1,CDC37,FABP1,GATA3,NIPSNAP1,GCA |
| protein domain specific binding | GNAI3,ICAL1,UNC13A,EZR,PPARA,GUSB,ABCC2,PRKAR2B,CNTLN,HIST1H4J |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CFLAR,CFLARA,CASP8L1,CASP14,CASP9,CASP10,CASP8 |
| cysteine-type endopeptidase activity | USP25,UCHL1,SFRP1,CASP6,USP14,CTSC,USP18,CTSLA,CASPA,CTSBB |
Interacting Protein
CASP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP2.
CRADD;PIDD1;PRKDC
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References
- Wilson, CH; Shalini, S; et al. Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. CELL DEATH & DISEASE 6:-(2015).
- Zhang, H; Sweezey, NB; et al. LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L391-L402(2015).
