C2

  • Official Full Name

    complement component 2

  • Overview

    Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

  • Synonyms

    C2;complement component 2;CO2;ARMD14;complement C2;C3/C5 convertase;complement component C2

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Cynomolgus
  • Glycine max
  • HEK293
  • Mammalian cells
  • Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II)
  • E.coli
  • Human Cell
  • His
  • Non
  • Fc
  • His&T7
  • His&Fc&Avi
  • N-His&C-HA
Cat.# Product name Source (Host) Species Tag Protein Length Price
C2-6878H Active Recombinant Human C2 protein(Met1-Leu752), His-tagged HEK293 Human His Met1-Leu752
C2-1012M Active Recombinant Mouse C2 Protein, His-tagged Mammalian cells Mouse His Met1-Leu760
C2-98H Active Native Human C2 Protein Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II) Human Non
C2-26739TH Recombinant Human C2 E.coli Human Non
C2-480M Recombinant Mouse C2, His-tagged Human Cell Mouse His Met1-Leu760
C2-598H Recombinant Human Complement Component 2, His-tagged HEK293 Human His
C2-599H Recombinant Human Complement Component 2, Fc Chimera HEK293 Human Fc
C2-7265H Recombinant Human C2 protein, hFc-tagged HEK293 Human Fc Met1-Leu752
C2-7846H Recombinant Human C2 protein, His & T7-tagged E.coli Human His&T7 Ile245~His451
C2-7847R Recombinant Rat C2 protein, His & T7-tagged E.coli Rat His&T7 Asn473~Arg723
C2-001MCL Recombinant Mouse C2 cell lysate Human Cell Mouse Non
C2-3068HCL Recombinant Human C2 cell lysate Human Cell Human Non
C2-0620H Recombinant Human C2 Protein (Ile245-His451), N-His-tagged E.coli Human His Ile245-His451
C2-1032H Active Recombinant Human C2 protein, His-tagged HEK293 Human His 21-752 a.a.
C2-1143M Recombinant Mouse C2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
C2-1143M-B Recombinant Mouse C2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
C2-1878C Active Recombinant Cynomolgus C2 protein, His-tagged HEK293 Cynomolgus His Ala 21 - Leu 752
C2-773G Recombinant Glycine max Leghemoglobin C2, His&HA-tagged E.coli Glycine max N-His&C-HA 2-145aa

    Involved Pathway

    C2 involved in several pathways and played different roles in them. We selected most pathways C2 participated on our site, such as Complement and coagulation cascades,Pertussis,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Staphylococcus aureus infection HLA-DOA,C1QC,H2-AB1,PLG,DSG1C,CFH,HLA-DRB3,MASP1,C3,CFI
    Systemic lupus erythematosus HIST1H2BJ,HIST1H2BD,TROVE2,GRIN2B,GM14478,HIST1H3I,SNRPD3,HIST1H2AG,HLA-DRB4,HLA-DRB1
    Complement and coagulation cascades CFI,C3,CR1L,F3,SERPINE1,GM5077,F10,KNG1,Hc,F9
    Pertussis CALM3,MAPK3,CALML3,MAPK13,C1QB,CASP1,IL12A,SERPING1,GNAI2,TICAM2

    Protein Function

    C2 has several biochemical functions, for example, metal ion binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C2 itself. We selected most functions C2 had, and list some proteins which have the same functions with C2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding TENC1,TGM2,LIMK1A,CYP8B1,ZDHHC3A,Car12,PFKMB,DAGLB,ZNF436,GFI1B
    serine-type endopeptidase activity EGFBP2,PRSS37,ST14A,KLK14,CELA3B,PCSK2,MASP2,TMPRSS11G,Acr,PRSS41

    Interacting Protein

    C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of C2.

    q81l39_bacan

    Resources

    Research Area

    Serine Proteases and Regulators
    Classical Complement Pathway

    References

    • Kahle, J; Orlowski, A; et al. Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. THROMBOSIS AND HAEMOSTASIS 113:396-405(2015).
    • Shetty, KA; Kosloski, MP; et al. Soy Phosphatidylinositol Containing Nanoparticle Prolongs Hemostatic Activity of B-Domain Deleted Factor VIII in Hemophilia A Mice. JOURNAL OF PHARMACEUTICAL SCIENCES 104:388-395(2015).

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