Arsa
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Official Full Name
arylsulfatase A -
Overview
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010] -
Synonyms
ARSA;arylsulfatase A;MLD;ASA;cerebroside-sulfatase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- Human Cell
- HEK293T
- In Vitro Cell Free System
- Sf9 Insect Cell
- His
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
Arsa involved in several pathways and played different roles in them. We selected most pathways Arsa participated on our site, such as Sphingolipid metabolism,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Arsa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | SERINC1,LASS5,ENPP7,SGMS1,PPM1LA,CERS3B,ARSF,NEU3.1,CERS2A,CERS4A |
| Lysosome | GNPTG,GGA2,IDS,AP3B1,GNS,NAGPA,Ctsl,FUCA1,ATP6V0CB,NAPSA |
Protein Function
Arsa has several biochemical functions, for example, arylsulfatase activity,calcium ion binding,cerebroside-sulfatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Arsa itself. We selected most functions Arsa had, and list some proteins which have the same functions with Arsa. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CD248A,PCDHA5,ANXA5,CHP,CALM3A,BMP1A,CBLC,CAPN2,SYT5A,TBC1D8B |
| arylsulfatase activity | ARSI,SULF2,ARSG,ARSB,ARSJ,SULF1,ARSE,ARSD,ARSK,ARSH |
| sulfuric ester hydrolase activity | STS,SGSH,GALNS,GNS,SULF2B,SULF2A,GNSB,GNSA |
| protein binding | BIRC2,TTC5,NCALD,TMEM93,LRRC33,ATP6V1B2,KCNJ9,TPRKB,MAGOHB,KIAA1524 |
Interacting Protein
Arsa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arsa here. Most of them are supplied by our site. Hope this information will be useful for your research of Arsa.
TRIP13;TFAP2A;CETN2;PPIC;CLEC4G;xylB
Resources
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References
- Mitsunaga-Nakatsubo, K; Kusunoki, S; et al. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. MEDICAL MOLECULAR MORPHOLOGY 42:63-69(2009).
- Kurdi-Haidar, B; Heath, D; et al. Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 46:1243-1248(1998).
