Apaf1
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Official Full Name
APAF1 apoptotic peptidase activating factor 1 -
Overview
Apaf-1 is a cytosolic protein that rests in a latent state until bound by cytochrome c (Apaf-2). The resulting Apaf-1/cytochrome c complex associates with the zymogen form of caspase-9 (Apaf-3) in the presence of dATP or ATP, promoting the autocatalytic activation of caspase-9. This antibody will be useful in studies of the activation of caspases through Apaf-1 and also in metastatic melanomas where Apaf-1 is inactivated which leads to defects in the execution of apoptotic cell death. -
Synonyms
APAF1;apoptotic peptidase activating factor 1;apoptotic peptidase activating factor , apoptotic protease activating factor;apoptotic protease-activating factor 1;APAF 1;CED4;APAF-1;DKFZp781B1145
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- Yeast
- HEK293
- His
- His&T7
- GST
- Non
- His&B2M
- His&Fc&Avi
Involved Pathway
Apaf1 involved in several pathways and played different roles in them. We selected most pathways Apaf1 participated on our site, such as p signaling pathway,Apoptosis,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Apaf1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | NDUFA9,MT-ND1,PRKACA,NDUFS1,mt-Atp8,NDUFA6,UQCRB,NDUFC1,NDUFB7,NDUFS8 |
| Apoptosis | NFKB1,HRK,PPP3CA,HDR,IRAK1,IL1B2,CAPN2A,IRF4,PTBP3,AKT1 |
| Amyotrophic lateral sclerosis (ALS) | PPP3CB,TRP53,BAX,TOMM40L,NEFM,MAPK14,CASP1,CYCS,BAD,PRPH |
| Tuberculosis | SYK,TLR4,IFNA13,AKT1,HLA-DMB,FCGR2A,IL10RA,PPP3CB,CORO1A,TGFB2 |
| Small cell lung cancer | ITGB1,PTK2,LAMB2,XIAP,ITGA6,CCNE2,PIK3CD,TRAF5,PIK3CA,ITGA2B |
| Hepatitis B | PIK3CD,TGFB2,PIK3CB,IKBKG,IFNB1,PIK3R2,MAP3K1,IFNA10,STAT6,PTEN |
| Legionellosis | TLR2,HSPA2,PYCARD,ITGB2L,TLR4,SAR1B,NAIP6,CASP9,CASP1,Itgam&Itgb2 |
| p signaling pathway | CDK1,RCHY1,SIAH1A,GTSE1,LRDD,COP1,MDM2,ZMAT3,CYCSB,RPRM |
| Alzheimers disease | LRP1,AKR1C1,COX6B1,CDK5,SNCA,NDUFC2,NDUFA13,ATP2A1,BACE2,UQCRQ |
Protein Function
Apaf1 has several biochemical functions, for example, ADP binding,ATP binding,cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Apaf1 itself. We selected most functions Apaf1 had, and list some proteins which have the same functions with Apaf1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activator activity involved in apoptotic process | NLRP12,MAPK9,PYCARD,NOD1,CTSH,GNB2L1,CARD8,BCL2L13,RPS27L,BAD |
| identical protein binding | KHDC1A,RALYL,APOE,ENTPD2,DHX8,CLDN10,SDF4,HCN4,CHMP4B,RPE |
| protein binding | DZIP1L,S100A12,AMIGO2,RAB38,AZIN2,NRADD,ZBTB16,ARHGEF15,LARS,NKRF |
| ADP binding | MYH9,MIEF1,ME1,LONP1,TAP1,ATP1A1,CYB5R3,GLUD1,MYO7A,MYO6 |
| heat shock protein binding | FKBP4,FKBP5,SSUH2RS1,DNAJA3,DNAJA3B,DNAJA4,DMPK,PDXP,DNAJB6,GPR37 |
| ATP binding | ATAD1A,CDK19,FGFR1A,MYO6,PDPK1A,DGKE,ATP2A1L,LACE1A,SMC5,GSK3AA |
| nucleotide binding | SLIRP,RNPS1,TUBB5,DYRK1AA,CELF6,EWSR1B,INSRA,HNRNPD,EIF4BA,HNRNPA0L |
Interacting Protein
Apaf1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Apaf1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Apaf1.
CASP9
Apaf1 Related Signal Pathway
Resources
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References
- Gressner, O; Schilling, T; et al. TAp63 alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO JOURNAL 24:2458-2471(2005).
- Brydges, S; Kastner, DL; et al. The systemic autoinflammatory diseases: Inborn errors of the innate immune system. CURRENT CONCEPTS IN AUTOIMMUNITY AND CHRONIC INFLAMATION 305:127-160(2006).
