AHSG
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Official Full Name
alpha-2-HS-glycoprotein -
Overview
Alpha-2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. -
Synonyms
AHSG;alpha-2-HS-glycoprotein;AHS;A2HS;HSGA;FETUA;Alpha-2-Z-globulin;Ba-alpha-2-glycoprotein;Fetuin-A;Alpha-2-HS-glycoprotein chain A;Alpha-2-HS-glycoprotein chain B;PRO2743;OTTHUMP00000210158;OTTHUMP00000210159
Recombinant Proteins
- Human
- Mouse
- Rat
- Cattle
- Guinea pig
- Pig
- Bovine
- Macaca mulatta
- HEK293
- Mammalian Cells
- E.coli
- Human
- Wheat Germ
- Insect Cells
- Human Cells
- Human Plasma
- Bovine
- In Vitro Cell Free System
- His
- Non
- His&GST
- His&T7
- GST
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
AHSG involved in several pathways and played different roles in them. We selected most pathways AHSG participated on our site, such as BMP receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHSG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMP receptor signaling | NOG,SOSTDC1,RGMA,SKI,CALML4,RGMB,CTDSP2,CTDSPL,CHRDL1,CTDSP1 |
Protein Function
AHSG has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity,endopeptidase inhibitor activity,kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AHSG itself. We selected most functions AHSG had, and list some proteins which have the same functions with AHSG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase inhibitor activity | SOCS1,LRP6,RHOH |
| cysteine-type endopeptidase inhibitor activity | CST3,AHSG1,SERPINB3,WFDC2,BIRC7,CARD18,CSTL1,Cstb,PTTG1,CST11 |
| endopeptidase inhibitor activity | SERPINA1D,SERPIND1,STFA1,C5,C3A.2,SPINT2,MUG1,USP14,C4A,Serpina1b |
Interacting Protein
AHSG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHSG here. Most of them are supplied by our site. Hope this information will be useful for your research of AHSG.
Hsd17b7;ABL1;Smad3;Mad2l1;AKT1;CDC42;GRB2;d-mannose;ALB;ATF2
Resources
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References
- Biswas, S; Sharma, S; et al. Identification of Novel Autoantigen in the Synovial Fluid of Rheumatoid Arthritis Patients Using an Immunoproteomics Approach. PLOS ONE 8:-(2013).
- Fernandez-Grijalva, AL; Aguilar-Lemarroy, A; et al. Alpha 2HS-glycoprotein, a tumor-associated antigen (TAA) detected in Mexican patients with early-stage breast cancer. JOURNAL OF PROTEOMICS 112:301-312(2015).
