ADAM17
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Official Full Name
ADAM metallopeptidase domain 17 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM17;ADAM metallopeptidase domain 17;CSVP;TACE;NISBD;ADAM18;CD156B;disintegrin and metalloproteinase domain-containing protein 17;TNF-alpha convertase;snake venom-like protease;TNF-alpha converting enzyme;ADAM metallopeptidase domain 18;tumor necrosis factor, alpha, converting enzyme
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Insect Cell
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- Human Cell
- Mammalian cells
- E. coli
- E.coli expression system
- Non
- His
- GST
- His&T7
- His&Fc&Avi
- N-His
Involved Pathway
ADAM17 involved in several pathways and played different roles in them. We selected most pathways ADAM17 participated on our site, such as Notch signaling pathway,Alzheimers disease,Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | LYN,ATP6V1H,IKBKG,MAPK12,MAPK11,IL-8,MET,CCL5,ATP6V0A2,MAPK8 |
| Notch signaling pathway | CTBP2,NCSTN,ADAM17A,ADAM12,HER9,MFAP2,NOTCH2,CTBP2A,HER6,KAT2B |
| Alzheimers disease | IL1B2,NDUFA7,COX6A2,APH1C,UQCRC1,SDHA,NDUFS7,SNCA,NDUFA8,CASP12 |
Protein Function
ADAM17 has several biochemical functions, for example, Notch binding,PDZ domain binding,SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM17 itself. We selected most functions ADAM17 had, and list some proteins which have the same functions with ADAM17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Notch binding | NCOR2,SNW1,AAK1,JAG1,NOTCH1,DNER,GALNT11,JAG2,NOV,CHAC1 |
| metalloendopeptidase activity | MMP14B,ADAMTS13,MMEL1,ECE1,ADAMTS9,HE2,ADAM7,ADAM19,ADAMTS18,MMP19 |
| SH3 domain binding | WIPF3,PLSCR1,SH2D2A,ARHGAP17,GJA1,NCF1,SH3BP5L,HCLS1,EVL,SOS1 |
| protein binding | RDH12,SENP3,TWIST1,ULK3,CEP76,PHF15,BTG3,TUBB2B,EGLN2,CDK5 |
| integrin binding | COL3A1,ACTN4,PPAP2B,DST,MFGE8,THBS1,ICAM1,CD9,ICAM5,ADAMTS13 |
| interleukin-6 receptor binding | CNTF,PYCARD,IL6,ERAP1 |
| metallopeptidase activity | ACE,PSMD14,ADAMTS4,BMP1A,ADAM23,YME1L1,LNPEP,MEP1A.1,CHMP1A,DPEP3 |
| zinc ion binding | VDR,RNF135,RPH3A,TRIM35,LMO7,RUNX1,TRIM40,ZMIZ2,MORC3B,PGLYRP4 |
| PDZ domain binding | SSTR2,GRIA1,ARHGEF16,PLEKHA1,SNTA1,KIDINS220B,PROSAPIP1,LPAR1,TGFBR3,ATP2B4 |
Interacting Protein
ADAM17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM17.
DLG1;MAD2L1;APP;ITGB1;PDIA3;JAG1;TGFA;PTPN3;thiF;Sgol2
ADAM17 Related Signal Pathway
Resources
Research Area
ADAMs on Endothelial CellsRenal Markers
Notch Family
Inflammatory Mediators
Alzheimer's Disease
Metalloproteases and Regulators
Inflammatory Bowel Diseases Therapeutic Targets
Related Services
Related Products
References
- Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell renal cell carcinomas: Implication for patients' prognosis. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014).
- Arenaccio, C; Chiozzini, C; et al. Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).
