ACVR1
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Official Full Name
activin A receptor, type I -
Overview
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta);superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor;serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors;are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a;transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are;essential for signaling; and type II receptors are required for binding ligands and for expression of type I;receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I;receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional;response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia;ossificans progressive. -
Synonyms
ACVR1;activin A receptor, type I;ACVRLK2;activin receptor type-1;ACVR1A;ALK2;SKR1;activin receptor type I;hydroxyalkyl-protein kinase;activin receptor-like kinase 2;TGF-B superfamily receptor type I;activin A receptor, type II-like kinase 2;se
Recombinant Proteins
- Human
- Mouse
- Canine
- Rhesus macaque
- Chicken
- Rat
- Cynomolgus
- Mus musculus
- Human Cell
- Sf9 Insect Cell
- HEK293
- Insect Cell
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- BTI-Tn-5B1-4 Cell
- Nicotiana Benthamiana
- E.coli
- HEK293T
- In Vitro Cell Free System
- E. coli
- E.coli expression system
- Fc
- Non
- His&Fc
- C-His&hFc
- GST
- His&GST
- His
- Myc&DDK
- Flag
- HIS
- His&Fc&Avi
- N-GST
Involved Pathway
ACVR1 involved in several pathways and played different roles in them. We selected most pathways ACVR1 participated on our site, such as Cytokine-cytokine receptor interaction,TGF-beta signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | KLF4,ZFHX3,BMPR2,LHX5,WNT11,PIK3R1,PIK3CG,MYF5,INHBE,SMAD2 |
| Cytokine-cytokine receptor interaction | IL13RA1,GM2506,CCL8,CXCR3.2,LEPR,VEGFB,CXCL12A,IL12RB1,IL19,CCR9 |
| TGF-beta signaling pathway | ACVR2B,SMAD4,ID4,BAMBIA,BMPR2,NOG,GDF6A,TGFBR1A,INHBE,PITX2 |
Protein Function
ACVR1 has several biochemical functions, for example, ATP binding,SMAD binding,activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1 itself. We selected most functions ACVR1 had, and list some proteins which have the same functions with ACVR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | CAMK1DA,SYK,FYNB,MAP2K4B,COL4A3BP,PRKG1A,MAP4K3,ACVR1BA,RPS6KAL,CAMK2D2 |
| SMAD binding | MEF2A,TOB1,FOXH1,MAGI2,BMP2,SOD3,YY1,HIPK2,SKOR1B,SMAD2 |
| transforming growth factor beta binding | VASN,ENG,TGFBR3,TGFB3,TGFBR1,HYAL2,CD109,ACVRL1,LTBP1,ITGAV |
| transforming growth factor beta receptor activity, type I | TGFBR1,BMPR1B |
| peptide hormone binding | AGTR2,NPR2,PTH1R,MC3R,PRLR,GCGR,GHSR,CRHR2,NPR1,EDNRB |
| metal ion binding | ZNF239,MEP1A.1,NUDT17,ZFP750,NT5C2A,ACY1,ZIC5,MGAT4B,TDO2,PLA2G4AA |
| protein serine/threonine kinase activity | TSSK6,MAPK1,PSKH1,SRPK2,SPEG,CSNK1G2A,MAPK8,MAPK12A,ACVR2A,DCLK3 |
| transmembrane receptor protein serine/threonine kinase activity | ACVR1BA,TGFBR2,ACVR1L,BMPR2A,TGFBR1B,BMPR1BB,ACVR1B,ACVR2AA,ALPK2,ACVRL1 |
| contributes_to activin receptor activity, type I | ACVRL1 |
Interacting Protein
ACVR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1.
Smad6;Rab17;Rhod;Fbxo30;Ikbkb;Chn1;Nek8;Ubxn1;Fancl;Rab3b;Rhebl1;Plekhb1;TGFBR1;linkable pd173955 analogue;bosutinib;dasatinib;crizotinib
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