Recombinant Human Activin A Receptor, Type I, His-tagged

• Cat.No.: ACVR1-984H
• Product Overview: Recombinant human ACVR1 (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: ACVR1-984H
• Description: ACVR1 is a receptor serine/threonine kinase that is member of the ACVR family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ACVR1, but not TGFβRI (ACVR1), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1 pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 67 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 46 nmol/min/mg
• Purity: > 90 %
• Concentration: 0.1 ug/ul
• Sequences: 147-end
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: ALK1 pathway; ALK1 signaling events; ALK2 signaling events; Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Protein length: 147-end a.a.

Gene Information

• Gene Name: ACVR1 activin A receptor, type I [ Homo sapiens ]
• Official Symbol: ACVR1
• Synonyms: ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; activin receptor type-1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; Activin receptor type-1; EC 2.7.11.30; Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; TSR-I; OTTHUMP00000162806; OTTHUMP00000204626; OTTHUMP00000240120
• Gene ID: 90
• mRNA Refseq: NM_001105
• Protein Refseq: NP_001096
• MIM: 102576
• UniProt ID: Q04771
• Chromosome Location: 2q23-q24
• Function: ATP binding; SMAD binding; activin binding; contributes_to activin receptor activity, type I; follistatin binding; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity