SARS Coronavirus Main Proteinase Complexed With Inhibitor

• Cat.No.: CBCRY05

Specification

• Cat. No.: CBCRY05
• Background: The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).
• Protein Classification: Hydrolase
• Structure Weight: 69623.62
• Polymer: 1
• Molecule: 3C-like proteinase
• Chain Length: 306 amino acids
• PDB ID: 1UK4
• MMDB ID: 25518
• Source: E.coli
• Method: X-Ray Diffraction
• Resolution: 2.5Å
• Ligand Chemical Component: Chloroacetone
• Reference: Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.
• Tag: Non

Gene Information

• Gene Name: NEWENTRY
• Synonyms: 3C-like proteinase
• Gene ID: 2831005
• Function: RNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding