Retinoic acid, GMP Grade

• Cat.No.: Retinoic acid-16
• Product Overview: Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture.

Specification

• Description: Retinoic acid is an agonist of RAR nuclear receptors.
• Form: Solid, White to off-white
• Target: RAR/RXR; PPAR; Endogenous Metabolite; Autophagy
• In Vitro: Retinoic acid (GMP) time- and dose- dependently induces differentiation of EC cells and ES cells into specific cell types. Retinoic acid (GMP) induces partial differentiation of F9 embryonal carcinoma cells into endoderm cells. Retinoic acid (GMP) (100 nM; 2-8 d) promotes photoreceptor differentiation in early postnatal retinal cultures. Retinoic acid (GMP) (0.1 μM; 10-12 d) induces human SH-SY5Y neuroblastoma cells differentiation with long cell processes. Retinoic acid (GMP) (0-10 μM; 48 h) dose-dependently induces morphologic differentiation of LA-N-1 human neuroblastoma cells.
• In Vivo: Retinoic acid (GMP) (0.3 μM; embryos are immersed in tank water containing retinoic acid) accelerates of rod differentiation is observed following 24 and 48 hours of application in zebrafish.
• Solubility Data: DMSO: 50 mg/mL (166.42 mM; Need ultrasonic and warming)
• CAS: 302-79-4
• Formula: C20H28O2
• Molecular Mass: 300.44

Gene Information

• Pathway: Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor; Cell Cycle/DNA Damage; Autophagy
• Official Symbol: Retinoic acid
• Synonyms: Retinoic acid; Vitamin A acid; all-trans-Retinoic acid; ATRA