Recombinant Rhesus Monkey CDH2 Protein, hIgG4-tagged

• Cat.No.: CDH2-1742R
• Product Overview: Recombinant Rhesus monkey CDH2 Protein (XP_014977198 ( aa.160-724)) was expressed in human HEK293 cells with hIgG4 tag.

Specification

• Species: Rhesus macaque
• Source: HEK293
• Tag: hIgG4
• Protein Length: 160-724 a.a.
• Description: N-cadherin, also known as Cadherin-2 (CDH2) or neural cadherin (NCAD),a classical cadherin from the cadherin superfamily, composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. N-cadherin, as well as other cadherins, interact with N-cadherin on an adjacent cell in an anti-parallel conformation, thus creating a linear, adhesive "zipper". between cells. Cadherin-2 acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. In cardiac muscle, N-cadherin is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes.
• Form: PBS, pH7.4.
• Purity: > 95 %
• Applications: ELISA; WB; Immunogen
• Storage: -80 centigrade, Avoid freeze/thaw cycle.
• Concentration: 1 mg/mL

Gene Information

• Gene Name: CDH2 cadherin 2 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: CDH2
• Synonyms: CDH2; cadherin 2; type 1; N-cadherin (neuronal); NCAD; cadherin-2; CD325; CDHN; N cadherin; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2; N-cadherin (neuronal); calcium-dependent adhesion protein; neuronal; CDw325
• Gene ID: 711526
• mRNA Refseq: XM_015121712.1
• Protein Refseq: XP_014977198