Recombinant Rat Prom1 Protein, Fc-tagged, Alexa Fluor 647 conjugated

Cat.No. : Prom1-120RAF647
Product Overview : A DNA sequence encoding the rat PROM1 (F1MAN1) (Asn171-Tyr424) (Alexa Fluor 647 conjugated) was with the Fc region of mouse IgG1 at the N-terminus.
Availability February 08, 2025
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Species : Rat
Source : HEK293
Tag : Fc
ProteinLength : 490
Description : CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein which belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.
Form : Lyophilized
Molecular Mass : The recombinant rat PROM1 comprises 490 amino acids and predicts a molecular mass of 55.1 kDa. The apparent molecular mass of the recombinant protein is approximately 67 and 34 kDa in SDS-PAGE under reducing conditions due to glycosylation.
N-terminal Sequence Analysis : Asp
Endotoxin : < 1.0 EU/ μg of the protein as determined by the LAL method.
Purity : (79.2+14.5) % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 647 via amines
Excitation = 650 nm
Emission = 668 nm
Stability : Samples are stable for up to 12 months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -70 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile PBS, pH 7.4.
Gene Name Prom1 prominin 1 [ Rattus norvegicus (Norway rat) ]
Official Symbol Prom1
Synonyms Prom1; Prom; CD133; prominin 1; fudenine
Gene ID 60357
mRNA Refseq NM_021751
Protein Refseq NP_068519

Not For Human Consumption!

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