Recombinant Rat Hrh2 Protein

• Cat.No.: Hrh2-788R
• Product Overview: Recombinant Rat Histamine H2-Receptor was expressed in Sf9 insect cells.

Specification

• Species: Rat
• Source: Insect Cells
• Tag: Non
• Description: The histamine H2-receptor (H2R) belongs to the superfamily of seven transmembrane domain (7TM), G-protein-coupled receptors (GPCRs). The endogenous agonist for the H2R is histamine which is both neurotransmitter and autacoid. The H2R couples to Gs-proteins to mediate adenylate cyclase (AC) activation. In some systems, the H2R also couples to Gq-proteins and phospholipase C. Among the many responses mediated by the H2R are gastric acid secretion, smooth muscle relaxation, positive ionotropic and chronotropic effects on heart muscle, and inhibition of leukocyte function. The rat H2R was prepared from Sf9 cells infected with rat H2R-encoding baculovirus. In this system, the rat H2R couples to the Gsα-like G-proteins of the insect cells to mediate AC activation.
• Form: 75 mM Tris-HCl pH 7.4, 12.5 mM MgCl2 and 1 mM EDTA
• Molecular Mass: 33 kDa
• Storage: Store at -80 centigrade, avoid freeze/thaw cycles.

Gene Information

• Gene Name: Hrh2 histamine receptor H 2 [ Rattus norvegicus ]
• Official Symbol: Hrh2
• Synonyms: Hrh2
• Gene ID: 25461
• mRNA Refseq: NM_012965.3
• Protein Refseq: NP_037097.3
• UniProt ID: P25102