Hrh2
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Official Full Name
histamine receptor H2 -
Overview
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HRH2;histamine receptor H2;histamine H2 receptor;HH2R;gastric receptor 1;gastric receptor I;H2R
Recombinant Proteins
- Guinea Pig
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Canine
- Western lowland gorilla
- Dog
- Pan troglodytes
- Mus musculus
- Guinea pig
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- E.coli
- Non
- His
- Flag&His
- Avi&Fc&His
Involved Pathway
Hrh2 involved in several pathways and played different roles in them. We selected most pathways Hrh2 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hrh2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | SST,ATP1B3,KCNJ16,SLC9A4,ATP1A2,PLCB3,KCNE2,CALM4,GNAS,Adcy4 |
| Calcium signaling pathway | TRHR2,CACNA1D,PRKACG,ERBB3,AGTR1B,PLCE1,CALM4,ATP2A2,ITPR3,PHKG1B |
| Neuroactive ligand-receptor interaction | P2RX8,DRD2A,P2RX3,TAAR14G,GLP1R,CHRM5A,P2RX2,OPRK1,CALCRL,OPRD1 |
Protein Function
Hrh2 has several biochemical functions, for example, NOT dopamine binding,NOT dopamine neurotransmitter receptor activity, coupled via Gs,histamine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hrh2 itself. We selected most functions Hrh2 had, and list some proteins which have the same functions with Hrh2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine receptor activity | HRH3,HTR6,HRH1,HRH4 |
Interacting Protein
Hrh2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hrh2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hrh2.
cimetidine;aminopotentidine
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References
- Toubanaki, DK; Christopoulos, TK; et al. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. ANALYTICAL BIOCHEMISTRY 385:34-41(2009).
