Recombinant Rat Hap1 protein, His & GST-tagged

• Cat.No.: Hap1-1600R
• Product Overview: Recombinant Rat Hap1 aa. (Gln349~Arg584 (Accession # P54256)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Species: Rat
• Source: E.coli
• Tag: GST&His
• Protein Length: Gln349~Arg584
• Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 56.6kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >90%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 4.9

Gene Information

• Gene Name: Hap1 huntingtin-associated protein 1 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Hap1
• Synonyms: Hap1; huntingtin-associated protein 1; HAP1-A; HAP1-B; HAP-1
• Gene ID: 29430
• mRNA Refseq: NM_024133.2
• Protein Refseq: NP_077047.1
• UniProt ID: P54256