Recombinant Pig Carboxypeptidase B

Description :	Carboxypeptidase B, also well known as pancreatic procarboxy-peptidase B (PCPB), is a highly pancreas-specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitisand pancreatic graft rejection. As the prototype for those humanexopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preferencefor Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.
Species :	Pig
Form :	Lyophilized or Liquid
Molecular Mass :	The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 307-aa mature chain.The secreted PCPB zymogen is converted to enzymatically active CPB by limited proteolysis by trypsin.
Unit Definition :	One Unit hydrolyzes one micromole of hippuryl-L-arginine per minute at 25°C, pH 7.65.
Enzyme Unit :	≥70 units per mg protein.
Storage :	Store at -20 °C, for extended storage, conserve at -20 °C or -80 °C.
Concentration :	1 -10 mg/mL
Storage Buffer :	In 100 mM sodium chloride
Warning :	Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week.
Tag :	Non

Gene Name	CPB1 carboxypeptidase B1 (tissue) [ Sus scrofa(pig) ]
Official Symbol	CPB1
Synonyms	CPB1; CPB
Gene ID	397341
mRNA Refseq	NM_214169
Protein Refseq	NP_999334
UniProt ID	P09955
Chromosome Location	13; 13
Pathway	Pancreatic secretion, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem
Function	metallocarboxypeptidase activity; zinc ion binding