Recombinant Mouse Zyg11b Protein, Myc/DDK-tagged

• Cat.No.: Zyg11b-7134M
• Product Overview: Purified recombinant protein of Mouse zyg-ll family member B, cell cycle regulator (Zyg11b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 84 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Zyg11b zyg-ll family member B, cell cycle regulator [ Mus musculus (house mouse) ]
• Official Symbol: Zyg11b
• Synonyms: Zyg11b; zyg-ll family member B, cell cycle regulator; Gm431; D4Mgi2; D4Mgi23; mKIAA1730; 1110046I03Rik; 2810482G21Rik; protein zyg-11 homolog B; zyg-ll homolog B
• Gene ID: 414872
• mRNA Refseq: NM_001033634
• Protein Refseq: NP_001028806
• UniProt ID: Q3UFS0