Recombinant Mouse Zfp385a Protein, Myc/DDK-tagged

• Cat.No.: Zfp385a-7087M
• Product Overview: Purified recombinant protein of Mouse zinc finger protein 385A (Zfp385a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 40.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Zfp385a zinc finger protein 385A [ Mus musculus (house mouse) ]
• Official Symbol: Zfp385a
• Synonyms: Zfp385a; zinc finger protein 385A; Hzf; Zfp38; Zfp385; Znf385a; zinc finger protein 385A; hematopoietic zinc finger protein; zinc finger protein 385
• Gene ID: 29813
• mRNA Refseq: NM_013866
• Protein Refseq: NP_038894
• UniProt ID: Q8VD12