Recombinant Mouse Wdr5 Protein, MYC/DDK-tagged

• Cat.No.: Wdr5-1016M
• Product Overview: Purified recombinant protein of full-length mouse WD repeat domain 5 (Wdr5), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (PubMed:11551928). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity).
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 36.6 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wdr5 WD repeat domain 5 [ Mus musculus (house mouse) ]
• Official Symbol: Wdr5
• Synonyms: Wdr5; WD repeat domain 5; Big; Big-3; AA408785; AA960360; 2410008O07Rik; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3
• Gene ID: 140858
• mRNA Refseq: NM_080848
• Protein Refseq: NP_543124
• UniProt ID: P61965