Recombinant Human WDR5, His-tagged

• Cat.No.: WDR5-31543TH
• Product Overview: Recombinant full length Human WDR5 with an N terminal His tag; single, non-glycosylated polypeptide chain; 354 amino acids including tag, MWt 38.8 kDa.

Specification

• Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
• Protein length: 334 amino acids
• Conjugation: HIS
• Molecular Weight: 38.800kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.03% DTT, 0.58% Sodium chloride, 0.24% Tris
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMATEEKKPETEAARAQPTPS SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH TDVVISTACHPTENIIASAALENDKTIKLWKSDC
• Sequence Similarities: Belongs to the WD repeat WDR5/wds family.Contains 7 WD repeats.

Gene Information

• Gene Name: WDR5 WD repeat domain 5 [ Homo sapiens ]
• Official Symbol: WDR5
• Synonyms: WDR5; WD repeat domain 5; WD repeat-containing protein 5; SWD3; Set1c WD40 repeat protein; homolog (S. cerevisiae)
• Gene ID: 11091
• mRNA Refseq: NM_017588
• Protein Refseq: NP_060058
• MIM: 609012
• Uniprot ID: P61964
• Chromosome Location: 9q34
• Pathway: Circadian rhythm pathway, organism-specific biosystem
• Function: contributes_to histone methyltransferase activity (H3-K4 specific); protein binding