Recombinant Mouse Wdr1 Protein, Myc/DDK-tagged

• Cat.No.: Wdr1-6972M
• Product Overview: Purified recombinant protein of Mouse WD repeat domain 1 (Wdr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage. Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt.
• Molecular Mass: 66.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Wdr1 WD repeat domain 1 [ Mus musculus (house mouse) ]
• Official Symbol: Wdr1
• Synonyms: WDR1; WD repeat domain 1; WD repeat-containing protein 1; WD40 repeat protein 1; actin-interacting protein 1; Aip1; rede; D5Wsu185e
• Gene ID: 22388
• mRNA Refseq: NM_011715
• Protein Refseq: NP_035845
• UniProt ID: O88342