Recombinant Mouse Trp73 Protein, Myc/DDK-tagged

• Cat.No.: Trp73-6675M
• Product Overview: Purified recombinant protein of mouse full-length transformation related protein 73 (Trp73), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.
• Molecular Mass: 64.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trp73 transformation related protein 73 [ Mus musculus (house mouse) ]
• Official Symbol: Trp73
• Synonyms: Trp73; transformation related protein 73; p7; TAp; p73; Tp73; TAp73; delta; deltaNp73
• Gene ID: 22062
• mRNA Refseq: NM_001126330
• Protein Refseq: NP_001119802
• UniProt ID: Q9JJP2