Recombinant Mouse Trib1 Protein, Myc/DDK-tagged

• Cat.No.: Trib1-6640M
• Product Overview: Purified recombinant protein of mouse full-length tribbles pseudokinase 1 (Trib1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. Promotes CEBPA degradation and inhibits its function. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.
• Molecular Mass: 41.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trib1 tribbles pseudokinase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Trib1
• Synonyms: TRIB1; tribbles homolog 1 (Drosophila); tribbles homolog 1; Trb1; TRB-1; A530090O15Rik
• Gene ID: 211770
• mRNA Refseq: NM_144549
• Protein Refseq: NP_653132
• UniProt ID: Q8K4K4