Recombinant Mouse Tor1a Protein, Myc/DDK-tagged

• Cat.No.: Tor1a-6584M
• Product Overview: Purified recombinant protein of mouse full-length torsin family 1, member A (torsin A) (Tor1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 37.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tor1a torsin family 1, member A (torsin A) [ Mus musculus (house mouse) ]
• Official Symbol: Tor1a
• Synonyms: TOR1A; torsin family 1, member A (torsin A); torsin-1A; dystonia 1 protein; torsin family 1 member A; DQ2; Dyt1; torsinA; MGC18883
• Gene ID: 30931
• mRNA Refseq: NM_144884
• Protein Refseq: NP_659133
• UniProt ID: Q9ER39