Recombinant Mouse TMED1 Protein, Fc-tagged

• Cat.No.: TMED1-543M
• Product Overview: Recombinant Mouse TMED1 (NP_034874.2) (Met1-Asn194) was expressed with the Fc region of human IgG1 at the C-terminus.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• ProteinLength: Met1-Asn194
• Description: TMED1 belongs to the EMP24/GP25L family. It contains 1 GOLD domain and is widely expressed. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.
• Predicted N Terminal: Gly 25
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant mouse TMED1 consists of 408 amino acids and predicts a molecular mass of 46 kDa.
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 85 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: Tmed1 transmembrane emp24 domain containing 1 [ Mus musculus ]
• Official Symbol: TMED1
• Synonyms: TMED1; transmembrane emp24 domain containing 1; transmembrane emp24 domain-containing protein 1; p24gamma1; p24 family protein gamma-1; lymphocyte antigen 84 ligand; interleukin 1 receptor-like 1 ligand; interleukin-1 receptor-like 1 ligand; putative T1/ST2 receptor-binding protein; St2l; Ly84l; Il1rl1l
• Gene ID: 17083
• mRNA Refseq: NM_010744
• Protein Refseq: NP_034874