Recombinant Mouse Tlr7 Protein, His-tagged

• Cat.No.: Tlr7-836M
• Product Overview: Recombinant Mouse Tlr7 Protein (Asn275-Phe444) with an N-terminal Met and a C-terminal 6-His tag was expressed in E.coli.

Specification

• Description: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively.
• Source: E. coli
• Species: Mouse
• Tag: His
• Molecular Mass: 21 kDa
• N-terminal Sequence Analysis: Met
• Endotoxin: < 1.0 EU/μg of the protein by the LAL method.
• Purity: > 95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in HCl.
• Reconstitution: Reconstitute at 200 μg/mL in 10 mM HCl.
• Shipping: The product is shipped at ambient temperature.
• Protein length: 275-444 a.a.

Gene Information

• Gene Name: Tlr7 toll-like receptor 7 [ Mus musculus (house mouse) ]
• Official Symbol: Tlr7
• Synonyms: Tlr7; toll-like receptor 7; toll-like receptor 7; Toll like receptor 7
• Gene ID: 170743
• mRNA Refseq: NM_133211
• Protein Refseq: NP_573474
• UniProt ID: P58681