Recombinant Mouse Tlk1 Protein, Myc/DDK-tagged

• Cat.No.: Tlk1-6449M
• Product Overview: Purified recombinant protein of mouse full-length tousled-like kinase 1 (Tlk1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 87.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tlk1 tousled-like kinase 1 [ Mus musculus (house mouse) ]
• Official Symbol: Tlk1
• Synonyms: TLK1; tousled-like kinase 1; serine/threonine-protein kinase tousled-like 1; 4930545J15Rik
• Gene ID: 228012
• mRNA Refseq: NM_172664
• Protein Refseq: NP_766252
• UniProt ID: Q8C0V0