TLK1
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Official Full Name
tousled-like kinase 1 -
Overview
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin;assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell;cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this;protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different;isoforms have been found for this gene. -
Synonyms
TLK1;tousled-like kinase 1;serine/threonine-protein kinase tousled-like 1;KIAA0137;PKU BETA;SNARE protein kinase SNAK;serine threonine protein kinase;PKU-beta
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect Cells
- Sf9 Insect Cell
- Insect Cell
- HEK293
- Mammalian cells
- HEK293T
- Insect (sf21)
- GST
- His&GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
TLK1 involved in several pathways and played different roles in them. We selected most pathways TLK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TLK1 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by TLK1 itself. We selected most functions TLK1 had, and list some proteins which have the same functions with TLK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | DAW1,TARS2,C2orf28,C14orf1,ZNF75A,RSPH3A,FAM176A,TMEM44,SLC46A3,GGA1 |
Interacting Protein
TLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLK1.
TPM3;LUZP4;Dynll1;ASF1B;YWHAE;UBE3C;pykA;ppsC;uup;ASF1A;SNAP23
Resources
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References
- Klimovskaia, IM; Young, C; et al. Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication. NATURE COMMUNICATIONS 5:-(2014).
- Pascoalino, B; Dindar, G; et al. Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei. NUCLEIC ACIDS RESEARCH 42:2906-2918(2014).
