Recombinant Mouse Timeless Protein, Myc/DDK-tagged

• Cat.No.: Timeless-6430M
• Product Overview: Purified recombinant protein of mouse full-length timeless homolog (Drosophila) (cDNA clone MGC:73470 IMAGE:6837105), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 122 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Timeless timeless circadian clock 1 [ Mus musculus (house mouse) ]
• Official Symbol: Timeless
• Synonyms: Timeless; timeless circadian clock 1; ti; tim; C77407; Debt69; protein timeless homolog; mTim; timeless homolog
• Gene ID: 21853
• mRNA Refseq: NM_011589
• Protein Refseq: NP_035719
• UniProt ID: Q9R1X4