Recombinant Mouse TFR2 protein, mouse IgG1 Fc-tagged, low endotoxin

• Cat.No.: TFR2-361M
• Product Overview: Recombinant Mouse TFR2 protein (Arg103-Phe798)(low endotoxin), fused to Mouse IgG1 Fc tag at N-terminus, was expressed in human 293 cells (HEK293).

Specification

• Description: Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
• Source: HEK293
• Species: Mouse
• Tag: mFc
• Form: Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.
• Protein length: 696
• Endotoxin: Less than 0.1 EU per ug by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: Tfr2
• Official Symbol: Tfr2
• Synonyms: Trfr2
• Gene ID: 50765
• mRNA Refseq: NM_001289509.1
• Protein Refseq: NP_001276438.1
• UniProt ID: Q9JKX3