Recombinant Mouse Tbxas1 Protein, Myc/DDK-tagged

• Cat.No.: Tbxas1-6324M
• Product Overview: Purified recombinant protein of mouse full-length thromboxane A synthase 1, platelet (Tbxas1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 60.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tbxas1 thromboxane A synthase 1, platelet [ Mus musculus (house mouse) ]
• Official Symbol: Tbxas1
• Synonyms: TBXAS1; thromboxane A synthase 1, platelet; thromboxane-A synthase; TXA synthase; cytochrome P450 5A1; TS; TXS; CYP5; THAS; TXAS; CYP5A1
• Gene ID: 21391
• mRNA Refseq: NM_011539
• Protein Refseq: NP_035669
• UniProt ID: P36423